5-Bromo-4-fluoro-2-hydroxybenzaldehyde CAS 399-00-8
| CAS No. | 399-00-8 |
| Molecular Formula | C7H4BrFO2 |
| Molecular Weight | 219.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 219.01 g/mol gives 5-Bromo-4-fluoro-2-hydroxybenzaldehyde distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Bromo-4-fluoro-2-hydroxybenzaldehyde (CAS 399-00-8) is a high-purity analytical reference standard with the molecular formula C7H4BrFO2 and a molecular weight of 219.01 g/mol.
5-Bromo-4-fluoro-2-hydroxybenzaldehyde (C7H4BrFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Bromo-4-fluoro-2-hydroxybenzaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4BrFO2 |
| Molecular Weight | 219.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 3-Bromo-2-fluoro-6-hydroxybenzaldehyde (CAS 1160653-95-1)
- 5-Bromo-4-fluoro-1,3-benzodioxole, 97% (CAS 1226808-75-8)
- 6-Bromo-3-fluorosalicylaldehyde (CAS 1236079-57-4)
- 2-Bromo-7-fluoroimidazo[1,2-a]pyridine (CAS 1260790-45-1)
- 2-Bromo-4-fluoro-5-hydroxybenzaldehyde (CAS 1262989-52-5)
- 5-Bromo-2-fluoronicotinamide (CAS 1310416-55-7)
- 2-Bromo-3-fluorobenzoic Acid (CAS 132715-69-6)
- 3-Bromo-5-fluoroisonicotinamide (CAS 1353636-72-2)
Recommended Standards
- 5-Bromo-3-fluoropicolinamide (CAS 669066-90-4)
- 5-Bromo-6-fluoro-1,3-benzodioxole (CAS 94670-75-4)
- 5-Bromo-2-fluoro-4-hydroxybenzaldehyde (CAS 914397-21-0)
- 6-Bromo-2-fluoro-3-hydroxybenzaldehyde (CAS 935534-46-6)
- tert-Butyl 4-(((2-aminoethyl)thio)methyl)piperidine-1-carboxylate (CAS 1353976-72-3)
- Ethyl 1-(tert-butyl)-5-methyl-1H-pyrazole-4-carboxylate (CAS 98477-08-8)
- Methyl 1-(TriphenylMethyl)-2-aziridinecarboxylate (CAS 76357-18-1)
- Methyl (2S,4S)-4-(2-bromo-4-fluorophenoxy)-2-pyrrolidinecarboxylate hydrochloride (CAS 1354488-20-2)
- 6-((Cyanomethyl)thio)-[2,3'-bipyridine]-5-carbonitrile (CAS 118948-01-9)
- Ropivacaine Impurity 28 (CAS CATO-C4X-175328)
- 2-[(methylsulfonyl)methyl]-1H-benzimidazole (CAS 24092-75-9)
- 2-(4-Methoxyphenyl)quinoline-8-carboxamide (CAS 655222-47-2)
- 4-Isopropoxy-N-phenylaniline (CAS 101-73-5)
- Bradykinin-Like Neuropeptide (Aplysia californica) (H-1654.0001) (CAS 165174-60-7)
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