4,4'-((Oxybis(4,1-phenylene))bis(oxy))bis(3-(trifluoromethyl)aniline) CAS 399506-42-4
| CAS No. | 399506-42-4 |
| Molecular Formula | C26H18F6N2O3 |
| Molecular Weight | 520.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,4'-((Oxybis(4,1-phenylene))bis(oxy))bis(3-(trifluoromethyl)aniline) (CAS 399506-42-4) is a high-purity analytical reference standard with the molecular formula C26H18F6N2O3 and a molecular weight of 520.42 g/mol.
The molecular framework of 4,4'-((Oxybis(4,1-phenylene))bis(oxy))bis(3-(trifluoromethyl)aniline) (C26H18F6N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H18F6N2O3 |
| Molecular Weight | 520.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Oxybis Standards
- 4,4'-Oxybis(3-(2-bromoethyl)-1,2-dichlorobenzene) (CAS 3245-41-8)
- 4,4'-Oxybis(2,6-dibromoaniline) (CAS 61381-91-7)
- 3,3'-Oxybis(3-(chloromethyl)-1,1,1,5,5,5-hexamethyltrisiloxane) (CAS 17909-34-1)
- 3,3'-Oxybis(3-allyl-1,1,1,5,5,5-hexamethyltrisiloxane) (CAS 211931-07-6)
- 3,3'-Oxybis(3-cyclohexyl-1,1,5,5-tetramethyltrisiloxane) (CAS 302912-36-3)
- 10,10'-Oxybis(phenoxarsine) (CAS 58-36-6)
- 2,2'-(((Oxybis(4,1-phenylene))bis(azanediyl))bis(carbonyl))dibenzoic acid (CAS 82131-85-9)
- 2,2'-((((Oxybis(ethane-2,1-diyl))bis(oxy))bis(4,1-phenylene))bis(methaneylylidene))bis(1-phenylhydrazine) (CAS 203805-28-1)
Recommended Standards
- (E)-N'-(2,2,2-Trifluoro-1-(2-((4-fluorobenzyl)oxy)phenyl)ethylidene)-2-(trifluoromethyl)benzenesulfonohydrazide (CAS 2738683-58-2)
- Aciclovir Impurity 35 (CAS CATO-C4X-101035)
- Fmoc-Asn-OPfp (CAS 86060-99-3)
- Ledipasvir Impurity 48 (CAS CATO-C4X-331348)
- 4-(4,5-Dimethyl-4h-1,2,4-triazol-3-yl)-1,2,5-oxadiazol-3-amine (CAS 1343037-11-5)
- 1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-3-carbonitrile (CAS 91783-81-2)
- 4,4-Difluoropiperidine (CAS 21987-29-1)
- Trans-octahydro-2h-pyrano[3,2-c]pyridine (CAS 2007915-59-3)
- 3,3-Dimethyl-2-oxocyclohexane-1-carbaldehyde (CAS 76337-17-2)
- 3-Amino-3-deoxy-D-mannose HCl (CAS 69880-85-9)
- 4-{[(difluoromethyl)sulfonyl]methyl}benzoic acid (CAS 1000931-60-1)
- 1-(4-(3-Fluoropropoxy)benzyl)piperidine (CAS 860648-59-5)
- 1-Amino-1H-pyrrole-2,4-dicarbonitrile (CAS 937049-26-8)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
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