Metoclopramide impurity 131 CAS 40080-43-1
| CAS No. | 40080-43-1 |
| Molecular Formula | C10H9Cl2NO4 |
| Molecular Weight | 278.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Metoclopramide impurity 131 (CAS 40080-43-1, C10H9Cl2NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Metoclopramide impurity 131 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 278.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Metoclopramide impurity 131 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9Cl2NO4 |
| Molecular Weight | 278.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoclopramide Standards
- Metoclopramide Impurity 118 (CAS CATO-C4X-1415118)
- Metoclopramide Impurity 87 (CAS CATO-C4X-141587)
- Metoclopramide Impurity 107 (CAS CATO-C4X-1415107)
- Metoclopramide Impurity 27 (CAS CATO-C4X-141527)
- Metoclopramide Impurity 15 (CAS CATO-C4X-141515)
- Metoclopramide Impurity 76 (CAS CATO-C4X-141576)
- Metoclopramide Dimethyl Analog (CAS 18094-92-3)
- Metoclopramide N-Desethyl (CAS 27260-19-1)
Recommended Standards
- 2,6-dichloro-4-(((methoxycarbonyl)amino)methyl)benzoic acid (CAS CATO-C3D-262934)
- 2-Bromo-4-(5-hydroxy-3-methyl-1H-pyrazol-1-yl)benzonitrile (CAS 1008520-71-5)
- N-[(2,6-Dichlorobenzyl)oxy]-N-[(hydroxyimino)methyl]urea (CAS 338403-98-8)
- 4-Bromo-2-oxo-1-phenyl-1,2-dihydropyridine-3-carbaldehyde (CAS 1088987-94-3)
- Azelastine Impurity 35 (CAS CATO-C4X-139635)
- Diclofenac Methyl Ester (Aceclofenac EP Impurity B) (CAS 15307-78-5)
- Rosuvastatin Impurity 263 (CAS CATO-C4X-1169263)
- 3-(Aminomethyl)-5-cyclopropoxy-N-methylpicolinamide (CAS 1243471-39-7)
- 4-(Chloromethyl)-2-ethoxypyridine hydrochloride (CAS 2138565-25-8)
- 3-(4-Nitrophenyl)imidazolidine-2,4-dione (CAS 62101-57-9)
- Methyl 5-(2-amino-4-chlorophenyl)furan-2-carboxylate (CAS 886494-66-2)
- O-Desmethyl Mebeverine Acid (CAS 586357-02-0)
- Fluconazole EP Impurity G (R-Isomer) (CAS CATO-C4X-101965)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
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