Fluoxetine Impurity 4 CAS 402-45-9
| CAS No. | 402-45-9 |
| Molecular Formula | C7H5F3O |
| Molecular Weight | 162.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fluoxetine Impurity 4.
As a process- or degradation-related impurity, Fluoxetine Impurity 4 (CAS 402-45-9, C7H5F3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Fluoxetine Impurity 4 (C7H5F3O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5F3O |
| Molecular Weight | 162.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluoxetine Standards
- Fluoxetine Impurity 25 (CAS 27152-62-1)
- Fluoxetine EP Impurity A (CAS 42142-52-9)
- Fluoxetine Impurity 37 (CAS 101-98-4)
- Fluoxetine Impurity 27 (CAS 18776-12-0)
- Fluoxetine Impurity 01 (CAS 4850-49-1)
- Fluoxetine Impurity 23 (CAS 5053-63-4)
- Fluoxetine EP Impurity B (CAS 23580-89-4)
- Fluoxetine Impurity 03 (CAS 83554-67-0)
Recommended Standards
- 2-Hydroxybenzotrifluoride (CAS 444-30-4)
- 3-(trifluoromethyl)phenol (CAS 98-17-9)
- 5-Methyl-2-(trifluoromethyl)pyrimidine (CAS 198404-31-8)
- (Trifluoromethoxy)benzene (CAS 456-55-3)
- Methylprednisolone EP Impurity F (CAS 1625-39-4)
- Elagolix Impurity 10 (CAS CATO-C4X-206810)
- Empagliflozin Impurity 121 (CAS CATO-C4X-1065121)
- n-Ethyl-N-methyl-1,3-thiazolidine-4-carboxamide (CAS 1218601-47-8)
- TTTB6-2CHO (CAS 2127354-14-5)
- CAS 286460-79-5 (CAS 286460-79-5)
- (1,4-Difluorocyclohexyl)methanol (CAS 2306271-48-5)
- (5-Morpholinopyrimidin-2-yl)methanamine hydrochloride (CAS 1196155-79-9)
- (1S,2S)-rel-2-(2-Bromo-1,3-thiazol-5-yl)cyclopropan-1-amine (CAS 1431304-52-7)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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