5-Nitrothiophene-3-carboxylic Acid CAS 40357-96-8
| CAS No. | 40357-96-8 |
| Molecular Formula | C5H3NO4S |
| Molecular Weight | 173.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Nitrothiophene-3-carboxylic Acid (CAS 40357-96-8) is a high-purity analytical reference standard with the molecular formula C5H3NO4S and a molecular weight of 173.15 g/mol.
The molecular framework of 5-Nitrothiophene-3-carboxylic Acid (C5H3NO4S) is characterized by a carbohydrate-derived structure, an amide group, a sulfone group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Nitrothiophene-3-carboxylic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H3NO4S |
| Molecular Weight | 173.15 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1968 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Nitrothiophene Standards
- 2-Nitrothiophene-3-carboxylic acid (CAS 100114-16-7)
- 3-Nitrothiophene-2-carboxylic acid (CAS 89283-80-7)
- 3-Nitrothiophene-2-carboxamide (CAS 391680-93-6)
- 4-nitrothiophene-2-carboxamide (CAS 36050-08-5)
- 5-Nitrothiophene-2-carboxamide (CAS 5832-00-8)
- 5-Nitrothiophene-3-carboxamide (CAS 36050-09-6)
- 2-Acetyl-4-nitrothiophene (CAS 42791-51-5)
- 2-Acetyl-5-nitrothiophene (CAS 39565-00-9)
Recommended Standards
- Ethyl 2-amino-5-fluoro-1H-imidazole-4-carboxylate (CAS 89676-58-4)
- 3-Mercapto-5-oxo-4,5-dihydro-1,2,4-triazine-6-carboxylic acid (CAS 7338-75-2)
- Ethyl 5-amino-4-fluoro-1H-pyrazole-3-carboxylate (CAS 2484964-07-8)
- 2-Thioxodihydropyrimidine-4,5,6(1H)-trione 5-oxime (CAS 23036-77-3)
- tert-Butyl 8,10-dioxo-3,9-diazaspiro[5.5]undecane-3-carboxylate (CAS 1043384-94-6)
- cis-3-fluorooxan-4-ol (CAS 1422188-18-8)
- 1-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)ethan-1-amine (CAS 1025508-59-1)
- Ethyl 2-(benzo[d]thiazol-2-ylthio)acetate (CAS 24044-88-0)
- 3-(5-(4-Aminophenyl)-1,3,4-oxadiazol-2-yl)propanoic acid (CAS 15828-35-0)
- 4-Amino-2-bromo-6-isopropylphenol (CAS 15028-17-8)
- 3-((1-Oxo-1,2-dihydroisoquinolin-3-yl)amino)benzoic acid (CAS 500198-66-3)
- 2-(Cyclopropylmethyl)-4-(methoxymethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine (CAS 1422133-38-7)
- Euphorbol (CAS 566-14-3)
- Semaglutide-d5 (CAS CATO-C4X-2226153)
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