4-Fluorophenyl Acetate CAS 405-51-6
| CAS No. | 405-51-6 |
| Molecular Formula | C8H7FO2 |
| Molecular Weight | 154.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-Fluorophenyl Acetate (CAS 405-51-6), molecular formula C8H7FO2 and molecular weight 154.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Fluorophenyl Acetate (C8H7FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H7FO2 |
| Molecular Weight | 154.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluorophenyl Standards
- (2-Fluorophenyl)urea (CAS 656-31-5)
- 1-(3-Fluorophenyl)urea (CAS 770-19-4)
- 2-(3-Fluorophenyl)acetic Acid (CAS 331-25-9)
- 2-Fluorophenyl Acetate (CAS 29650-44-0)
- 3-Fluorophenyl Acetate (CAS 701-83-7)
- 2-(4-Fluorophenyl)acetic acid (CAS 405-50-5)
- (1-(3-Fluorophenyl)ethyl)hydrazine (CAS 1016526-56-9)
- (1-(2-Fluorophenyl)ethyl)hydrazine (CAS 1016751-09-9)
Recommended Standards
- Acetaminophen-13C2, 15N1 (CAS 360769-21-7)
- 2-(sulfamoylamino)acetic acid (CAS 1016857-92-3)
- 4'-Fluoro-3'-hydroxyacetophenone (CAS 949159-95-9)
- Dimethyl(phenyl)phosphine oxide (CAS 10311-08-7)
- 1-Butoxy-3-methoxybenzene (CAS 51241-32-8)
- 5-[4-(2-Methylpropyl)phenyl]-1H-pyrazole-3-carboxylic acid (CAS 1260228-57-6)
- N-Methyl-2-{2-[(piperidin-4-yl)methyl]phenyl}ethylamine Dihydrochloride (CAS 1172569-99-1)
- 2-Fluoro-2-(isoquinolin-4-yl)acetic acid (CAS 1517532-69-2)
- N-(4-chlorophenyl)-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxamide (CAS 860785-82-6)
- 5-Ethyl-2-oxo-1,3-dioxole-4-carboxylic acid (CAS 188525-88-4)
- 2-[(5-sulfanyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide (CAS 61607-12-3)
- N-Methyl-3,3-diphenylpropan-1-amine Hydrochloride (CAS 29768-15-8)
- 6-Methyl-2-(3-nitrophenyl)-1,3,6,2-dioxazaborocane-4,8-dione (CAS 1311484-45-3)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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