4-Chloro-7-(trifluoromethoxy)quinoline CAS 40516-31-2
| CAS No. | 40516-31-2 |
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-7-(trifluoromethoxy)quinoline (CAS 40516-31-2) is a high-purity analytical reference standard with the molecular formula C10H5ClF3NO and a molecular weight of 247.60 g/mol.
The molecular framework of 4-Chloro-7-(trifluoromethoxy)quinoline (C10H5ClF3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 8-Chloro-5-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-44-5)
- 8-Chloro-6-(trifluoromethyl)quinolin-4-ol (CAS 1065092-49-0)
- 6-Chloro-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-54-7)
- 5-Chloro-8-(trifluoromethyl)quinolin-4-ol (CAS 1065092-56-9)
- 1-(4-Chloro-1H-indol-3-yl)-2,2,2-trifluoro-ethanone (CAS 1119282-66-4)
- 2-Chloro-6-(5-trifluoromethylpyrazol-1-yl)pyridine (CAS 1150164-45-6)
- 2-Chloro-5-(4-(trifluoromethyl)phenyl)oxazole (CAS 1238893-96-3)
- 3-Chloro-2-(2H-pyrazol-3-yl)-5-trifluoromethyl-pyridine (CAS 1269361-42-3)
Recommended Standards
- 4-Chloro-6-(trifluoromethoxy)quinoline (CAS 927800-55-3)
- 4-Chloro-8-(trifluoromethoxy)quinoline (CAS 40516-42-5)
- 4-Chloro-6-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidine (CAS 2052590-02-8)
- 5-(2-Chloro-4-(trifluoromethyl)phenyl)oxazole (CAS 2364584-84-7)
- 2-([1,1'-Biphenyl]-4-yl)-N-((1-(hydroxymethyl)cyclopropyl)methyl)acetamide (CAS 1286724-77-3)
- (E)-[1-(4-Chlorophenyl)ethylidene][(6-{[(E)-[1-(4-chlorophenyl)ethylidene]amino]oxy}pyridin-2-yl)oxy]amine (CAS 337921-63-8)
- 5-methanesulfonyl-2-methoxybenzene-1-sulfonyl chloride (CAS 885052-33-5)
- 1-Ethyl-2-methyl-1H-imidazole (CAS 21202-52-8)
- Amisulpride-d (CAS 1794756-15-2)
- Letrozole Impurity 18 (CAS CATO-C4X-182918)
- 4-(Pyrrolidin-3-ylamino)benzonitrile (CAS 933056-16-7)
- Pitavastatin Impurity 80 (CAS CATO-C4X-103780)
- Ethyl 3-(3-chlorophenyl)-1H-1,2,4-triazole-5-carboxylate (CAS 1285003-71-5)
- Peptide Impurity 82 (CAS 10491-78-8)
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