4-Chloro-5-(trifluoromethoxy)quinoline CAS 40575-20-0
| CAS No. | 40575-20-0 |
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 4-Chloro-5-(trifluoromethoxy)quinoline (CAS 40575-20-0), a certified reference material (molecular formula C10H5ClF3NO, MW 247.60 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-Chloro-5-(trifluoromethoxy)quinoline is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 247.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3NO |
| Molecular Weight | 247.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 8-Chloro-5-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-44-5)
- 8-Chloro-6-(trifluoromethyl)quinolin-4-ol (CAS 1065092-49-0)
- 6-Chloro-8-(trifluoromethyl)quinolin-4(1H)-one (CAS 1065092-54-7)
- 5-Chloro-8-(trifluoromethyl)quinolin-4-ol (CAS 1065092-56-9)
- 1-(4-Chloro-1H-indol-3-yl)-2,2,2-trifluoro-ethanone (CAS 1119282-66-4)
- 2-Chloro-6-(5-trifluoromethylpyrazol-1-yl)pyridine (CAS 1150164-45-6)
- 2-Chloro-5-(4-(trifluoromethyl)phenyl)oxazole (CAS 1238893-96-3)
- 3-Chloro-2-(2H-pyrazol-3-yl)-5-trifluoromethyl-pyridine (CAS 1269361-42-3)
Recommended Standards
- 4-Chloro-2-methyl-6-(trifluoromethyl)pyrido[3,2-d]pyrimidine (CAS 2092788-67-3)
- 4-Chloro-6-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidine (CAS 2052590-02-8)
- 4-Chloro-2-(trifluoromethyl)quinolin-8-ol (CAS 886362-20-5)
- 4-Chloro-6-(trifluoromethoxy)quinoline (CAS 927800-55-3)
- Fmoc-azetidine-3-carboxylic acid (CAS 193693-64-0)
- 2-(4-Phenylpiperazin-1-yl)-N-(p-tolyl)acetamide (CAS 763124-68-1)
- 6-Hydroxybenzofuran-7-carbaldehyde (CAS 59254-31-8)
- Ethyl 3-amino-1H-pyrrole-2-carboxylateHCl (CAS 252932-49-3)
- 1,3-Dioxoisoindoline-2-carbonitrile (CAS 63571-77-7)
- ((3aR,5R,6R,6aS)-6-Fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol (CAS 1101107-87-2)
- 5-(4-Chloro-2-fluorobenzyl)-4-methylthiazol-2(3h)-imine (CAS 1153775-92-8)
- 2-(Chloromethyl)-3-cyano-4-(difluoromethyl)-6-iodopyridine (CAS 1806857-97-5)
- 6-Bromo-4-methylpyridine-2-sulfonyl chloride (CAS 1393582-71-2)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
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