Propofol Impurity 42 CAS 40677-31-4
| CAS No. | 40677-31-4 |
| Molecular Formula | C14H10O5 |
| Molecular Weight | 258.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Propofol Impurity 42 (CAS 40677-31-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10O5 and a molecular weight of 258.23 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system, Propofol Impurity 42 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 258.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H10O5 |
| Molecular Weight | 258.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
Related Propofol Standards
- Propofol Impurity 30 (CAS 2215-89-6)
- Propofol Impurity 50 (CAS CATO-C4X-147350)
- Propofol Impurity 58 (CAS CATO-C4X-147358)
- Propofol EP Impurity P (CAS 2095678-97-8)
- Propofol Impurity 31 (CAS 2918851-48-4)
- Propofol Impurity 47 (CAS CATO-C4X-147347)
- Propofol Impurity 52 (CAS CATO-C4X-147352)
- Propofol impurity 62 (CAS 110007-31-3)
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