1-(3-Chlorophenyl)-2-fluoroethan-1-ol CAS 40733-92-4
| CAS No. | 40733-92-4 |
| Molecular Formula | C8H8ClFO |
| Molecular Weight | 174.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(3-Chlorophenyl)-2-fluoroethan-1-ol (C8H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 1-(3-Chlorophenyl)-2-fluoroethan-1-ol (CAS 40733-92-4), a certified reference material (molecular formula C8H8ClFO, MW 174.60 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3-Chlorophenyl)-2-fluoroethan-1-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO |
| Molecular Weight | 174.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- (S)-1-(3-Chlorophenyl)-2-fluoroethan-1-ol (CAS 1446417-96-4)
- 2-(2-Chlorophenyl)-2-fluoroethanol (CAS 1558111-86-6)
- 4-Chlorophenyl Methyl Sulfoxide (CAS 934-73-6)
- 3-(3-chlorophenyl)propanal (CAS 136415-83-3)
- 3-(2-chlorophenyl)propanal (CAS 157433-36-8)
- N-(4-Chlorophenyl-1,2,3,4,5,6-13C6)acetamide (CAS 1329611-30-4)
- (S)-1-(3-chlorophenyl)-2-fluoroethan-1-amine (CAS 1932224-27-5)
- (R)-1-(3-chlorophenyl)-2-fluoroethan-1-amine (CAS 1932343-14-0)
Recommended Standards
- 1-(3-Chloro-4-fluorophenyl)ethan-1-ol (CAS 878572-03-3)
- 1-(4-Chloro-2-fluorophenyl)ethanol (CAS 933673-55-3)
- 1-(2-Chloroethoxy)-4-fluorobenzene (CAS 64010-10-2)
- 1-(4-Chloro-3-fluorophenyl)ethan-1-ol (CAS 339001-14-8)
- 5,7-Dibromo-1H-indazol-4-amine (CAS 1427460-73-8)
- 6-(3-Bromo-2,4,6-trimethoxyphenyl)-3-methyl-7-oxa-3-azabicyclo[4.1.0]heptane (CAS 252367-12-7)
- DEPAPD (CAS 20320-59-6)
- 1-Iodo-2-isopropyl-4-nitrobenzene (CAS 31539-92-1)
- (Cyclopropylmethyl)(1-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)amine (CAS 1156207-16-7)
- 1-(1-Methyl-1H-1,2,4-triazol-5-yl)propan-1-amine (CAS 959239-47-5)
- 2-(3-Methylcyclohexyl)pyrimidine-4-carboxylic acid (CAS 1342573-84-5)
- 2,6-Dichloro-4-(tert-pentyl)phenol (CAS 75908-77-9)
- 40782-45-4 Benzoyl chloride, 4-(2-methylpropoxy)- CTK1D4285 (CAS 40782-45-4)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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