1-(4-Chlorobenzyl)piperidin-3-ol CAS 408312-64-1
| CAS No. | 408312-64-1 |
| Molecular Formula | C12H16ClNO |
| Molecular Weight | 225.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(4-Chlorobenzyl)piperidin-3-ol (CAS 408312-64-1) is a high-purity analytical reference standard with the molecular formula C12H16ClNO and a molecular weight of 225.71 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 1-(4-Chlorobenzyl)piperidin-3-ol is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 225.71 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H16ClNO |
| Molecular Weight | 225.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorobenzyl Standards
- n-(3-Chlorobenzyl)tetrahydro-2h-pyran-4-amine (CAS 1154882-41-3)
- n-(2-Chlorobenzyl)tetrahydro-2h-pyran-4-amine (CAS 1154889-50-5)
- N-(4-chlorobenzyl)tetrahydro-2H-pyran-4-amine (CAS 1157009-59-0)
- 2-((2-Chlorobenzyl)(cyclopropyl)amino)ethanol (CAS 1249492-43-0)
- 2-((4-Chlorobenzyl)(cyclopropyl)amino)ethanol (CAS 1250794-81-0)
- 2-((3-Chlorobenzyl)(cyclopropyl)amino)ethanol (CAS 1250971-00-6)
- (S)-(1-(3-chlorobenzyl)pyrrolidin-2-yl)methanol (CAS 1333575-03-3)
- 3-(4-Chlorobenzyl)tetrahydro-2h-pyran-3-amine (CAS 1339854-70-4)
Recommended Standards
- 1-(3-Chlorobenzyl)piperidin-3-ol (CAS 414886-77-4)
- 1-(4-Chlorobenzyl)piperidin-4-ol (CAS 21937-62-2)
- 1-(2-Chlorobenzyl)piperidin-3-ol (CAS 414890-85-0)
- 2-(2-Chloro-4-methoxyphenyl)-4-methylpyrrolidine (CAS 603068-83-3)
- (E)-Methyl 1-acetyl-3-(ethoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (CAS 1168152-06-4)
- 2-(4-Benzyl-1-piperazinyl)-5-fluorophenylamine (CAS 937597-33-6)
- (3-Chloro-4-fluorobenzyl)(phenyl)sulfane (CAS 1443331-25-6)
- 2-(2H-1,3-Benzodioxol-5-yl)-3-bromo-8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 866145-82-6)
- (S)-2-(((tert-Butyldimethylsilyl)oxy)methyl)pyrrolidin-1-amine (CAS 95479-35-9)
- (S)-Benzyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-cyanopropanoate (CAS 1464137-23-2)
- Ethyl 2-methylene-5-oxopentanoate (CAS 138420-80-1)
- (2,4-Dimethoxy-phenyl)-carbamic acid tert-butyl ester (CAS 260391-75-1)
- N-((1-((S)-2-Amino-3-methylbutanoyl)piperidin-3-yl)methyl)-N-cyclopropylacetamide (CAS 1354032-79-3)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
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