4-Nitro-2-(trifluoromethyl)phenylboronic acid CAS 408359-15-9
| CAS No. | 408359-15-9 |
| Molecular Formula | C7H5BF3NO4 |
| Molecular Weight | 234.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Nitro-2-(trifluoromethyl)phenylboronic acid.
CATO supplies 4-Nitro-2-(trifluoromethyl)phenylboronic acid (CAS 408359-15-9), a certified reference material (molecular formula C7H5BF3NO4, MW 234.93 g/mol) for analytical method development and quality control.
The molecular framework of 4-Nitro-2-(trifluoromethyl)phenylboronic acid (C7H5BF3NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Nitro-2-(trifluoromethyl)phenylboronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5BF3NO4 |
| Molecular Weight | 234.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nitro Standards
- (4-Nitro-3-(trifluoromethyl)phenyl)boronic acid (CAS 1201325-91-8)
- (2-Nitro-6-(trifluoromethyl)phenyl)boronic acid (CAS 408359-14-8)
- 3-Nitro-4-(trifluoromethyl)benzoic Acid (CAS 116965-16-3)
- 2-Nitro-5-(trifluoromethyl)benzoic acid (CAS 1214373-54-2)
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Why CATO?
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