2-Chloro-5-(trifluoromethyl)phenol CAS 40889-91-6
| CAS No. | 40889-91-6 |
| Molecular Formula | C7H4ClF3O |
| Molecular Weight | 196.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-5-(trifluoromethyl)phenol is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-5-(trifluoromethyl)phenol (CAS 40889-91-6) is a high-purity analytical reference standard with the molecular formula C7H4ClF3O and a molecular weight of 196.55 g/mol.
The molecular framework of 2-Chloro-5-(trifluoromethyl)phenol (C7H4ClF3O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-5-(trifluoromethyl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF3O |
| Molecular Weight | 196.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (3-Chloro-2,4,5-trifluorophenyl)methanol (CAS 101513-79-5)
- 3-Chloro-2-(trifluoromethyl)phenol (CAS 106877-34-3)
- 5-Chloro-2-(trifluoromethyl)phenol (CAS 106877-35-4)
- 2-Chloro-6-(trifluoromethyl)phenol (CAS 106877-36-5)
- 2-Chloro-1-(difluoromethoxy)-4-fluoro-benzene (CAS 106969-09-9)
- 1-Chloro-2-(difluoromethoxy)-3-fluorobenzene (CAS 1136961-91-5)
- 1-Chloro-2,4,5-trifluoro-3-methoxybenzene (CAS 13332-10-0)
- 2-Chloro-1,4,5-trifluoro-3-methoxybenzene (CAS 13555-12-9)
Recommended Standards
- 5-Chloro-2-(difluoromethyl)-3-fluorophenol (CAS 2092102-01-5)
- 5-Chloro-4-(trifluoromethyl)pyridin-3-amine (CAS 1019108-11-2)
- 4-Chlorobenzo[1,2-c:3,4-c']bis([1,2,5]oxadiazole) (CAS 749923-28-2)
- 5-Chloro-6-(trifluoromethyl)pyridin-3-amine (CAS 102145-83-5)
- 5-((tert-Butylthio)methyl)isoxazol-3(2H)-one (CAS 89660-67-3)
- N-(2-(Furan-3-yl)ethyl)-2,2-diphenylacetamide (CAS 1428367-36-5)
- 3-Chloro-N-(2,3-dichlorophenyl)propanamide (CAS 349097-69-4)
- 1-(3-Chloro-4-methylphenyl)pyrrolidin-3-amine (CAS 1181309-51-2)
- 2-(3-Methoxyphenyl)thiazole-5-carboxylic acid (CAS 886370-57-6)
- 4,4-Difluoro-1-[(2-fluorophenyl)methyl]cyclohexane-1-carboxylic acid (CAS 1380300-84-4)
- Ethyl 2-(aminomethyl)-4-methylpentanoate hydrochloride (CAS 1049760-14-6)
- 4-Benzylpiperazine-1-carboximidamide sulfate (CAS 53502-40-2)
- 3-(2,4,6-Trimethoxyphenyl)prop-2-en-1-amine (CAS 1344859-14-8)
- Cholecystokinin Octapeptide (1-4) (desulfated) (CAS 80790-40-5)
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