4-(4-Carboxybutyl)benzoic Acid CAS 412281-97-1
| CAS No. | 412281-97-1 |
| Molecular Formula | C12H14O4 |
| Molecular Weight | 222.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Carboxybutyl)benzoic Acid.
4-(4-Carboxybutyl)benzoic Acid (CAS 412281-97-1) is a high-purity analytical reference standard with the molecular formula C12H14O4 and a molecular weight of 222.24 g/mol.
The molecular framework of 4-(4-Carboxybutyl)benzoic Acid (C12H14O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14O4 |
| Molecular Weight | 222.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
Related Carboxybutyl Standards
- (R)-3-(2-Carboxybutyl)benzoic acid (CAS 1464137-13-0)
- 4-{[(4-carboxybutyl)amino]methyl}benzoic acid (CAS 1087784-29-9)
- (4-Carboxybutyl-2,2,3,3-d4)triphenylphosphonium Bromide (CAS 42932-63-8)
- 4-Carboxybutyl(triphenyl)phosphanium;bromide (CAS 17814-85-6)
- 4-(((4-Carboxybutyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoic acid (CAS 329773-35-5)
Recommended Standards
- 4-(4-(Methoxymethyl)phenyl)-4-oxobutanoic acid (CAS 946736-10-3)
- 4-(4-Ethoxyphenyl)-4-oxobutanoic acid (CAS 53623-37-3)
- 4-(3-Phenylureido)butanoic acid (CAS 40421-99-6)
- 4-(4-Fluorophenyl)thiophene-2-carboxylic acid (CAS 918487-47-5)
- 3-(Furan-2-yl)acrylaldehyde (CAS 623-30-3)
- Rhodium(IV) oxide dihydrate (CAS 75748-03-7)
- (5-Propyl-1,2,4-oxadiazol-3-yl)methanamine (CAS 946776-71-2)
- 6-Methoxykaempferol 3-O-Rutinoside (CAS 403861-33-6)
- (6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine (CAS 67496-29-1)
- N-(3,5-Dichloropyridin-4-yl)-7-methoxybenzofuran-4-carboxamide (CAS 185400-39-9)
- 2-(((4-(Trifluoromethyl)phenyl)imino)methyl)phenol (CAS 1220247-60-8)
- 2-((9,10-Dioxo-9,10-dihydroanthracen-1-yl)amino)benzoic acid (CAS 19795-96-1)
- 1-(2-Phenylacetyl)pyrrolidine-3-carboxylic acid (CAS 1498112-48-3)
- Insulin Degludec Impurity 24 (CAS CATO-C4X-215724)
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