4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid CAS 412343-21-6
| CAS No. | 412343-21-6 |
| Molecular Formula | C12H20BClO3Si |
| Molecular Weight | 286.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid (CAS 412343-21-6) is a high-purity analytical reference standard with the molecular formula C12H20BClO3Si and a molecular weight of 286.63 g/mol.
The molecular framework of 4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid (C12H20BClO3Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenylboronic Acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H20BClO3Si |
| Molecular Weight | 286.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.5 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related tert Standards
- (3-(((Tert-butyldimethylsilyl)oxy)methyl)-4-chlorophenyl)methanamine (CAS 946000-12-0)
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- ((Tert-butyldimethylsilyl)imino)(fluoromethyl)(phenyl)-λ6-sulfanone (CAS 825638-25-3)
- (3-(((tert-Butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol-d2 (CAS 2883771-00-2)
- (3-(((tert-Butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol-d2-1 (CAS 2883771-14-8)
- (3-(((tert-Butyldimethylsilyl)oxy)methyl)tetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol (CAS 1788873-94-8)
- 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chloro-6-methoxypyridine (CAS 944407-72-1)
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Recommended Standards
- 3-t-Butyldimethylsilyloxy-4-chlorophenylboronic acid (CAS 2096337-83-4)
- 4-(Difluoromethyl)-6-methyl-5-nitropyridine-3-sulfonyl chloride (CAS 1805070-13-6)
- 1-(4-Chloro-3,5-dimethylphenyl)-2,2,3,3,3-pentafluoropropan-1-one (CAS 1443313-23-2)
- 2-(Difluoromethyl)-3-methyl-5-nitropyridine-4-sulfonyl chloride (CAS 1805435-73-7)
- 1-({[(cyclopropylcarbonyl)oxy]imino}methyl)-3-nitrobenzene 1359730-93-0 KS-00001S12 (CAS 1359730-93-0)
- Tetrahydrofolic Acid-13C5 (CAS CATO-C4X-139519)
- (4-Phenoxyphenyl)phosphonic acid (CAS 4042-62-0)
- Ropinirole-d3 Hydrochloride (CAS 1329611-00-8)
- 3,4-Dichloro-N-(4-chlorophenyl)benzenesulfonamide (CAS 640-59-5)
- N4-cyclopentyl-5-nitropyrimidine-4,6-diamine (CAS 450344-84-0)
- 4-Bromo-6-methoxy-2-methylpyrimidine (CAS 1592696-30-4)
- (6,7-Dimethoxy-3,4-dihydroisoquinolin-1-yl)methanamine dihydrochloride (CAS 92788-84-6)
- 5-(2,4-Dichlorophenyl)-1-(2-propylpentanoyl)pyrazolidin-3-one (CAS 740812-31-1)
- Tirzepatide Impurity 26 X TFA Salt (CAS CATO-C4X-324026)
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