1-Chloro-4-iodo-2-nitrobenzene CAS 41252-95-3
| CAS No. | 41252-95-3 |
| Molecular Formula | C6H3ClINO2 |
| Molecular Weight | 283.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Chloro-4-iodo-2-nitrobenzene (CAS 41252-95-3) is a high-purity analytical reference standard with the molecular formula C6H3ClINO2 and a molecular weight of 283.45 g/mol.
The molecular framework of 1-Chloro-4-iodo-2-nitrobenzene (C6H3ClINO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Chloro-4-iodo-2-nitrobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3ClINO2 |
| Molecular Weight | 283.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-Chloro-3-iodo-5-nitrobenzene (CAS 123158-76-9)
- 2-Chloro-6-iodoisonicotinic acid (CAS 1352830-60-4)
- 6-Chloro-4-iodopicolinic acid (CAS 1393570-86-9)
- 2-Chloro-3-iodopyridine-4-carboxylic acid (CAS 1423027-39-7)
- 4-Chloro-2-iodo-1-nitrobenzene (CAS 160938-18-1)
- 1-Chloro-2-iodo-3-nitrobenzene (CAS 32337-97-6)
- 1-Chloro-2-iodo-4-nitrobenzene (CAS 74534-15-9)
- 2-Chloro-1-iodo-3-nitrobenzene (CAS 683238-59-7)
Recommended Standards
- 2-Chloro-4-iodo-1-nitrobenzene (CAS 89284-60-6)
- (4-Ethyl-2-undecyl-4,5-dihydrooxazol-4-yl)methanol (CAS 24448-07-5)
- 2-Chloro-4-iodonicotinic Acid (CAS 544671-78-5)
- 2-Chloro-5-iodonicotinic acid (CAS 59782-86-4)
- (3-(Cyclopentanecarboxamido)phenyl)boronic acid (CAS 1175564-21-2)
- 4-(2,5-Dichlorophenyl)-5-methylthiazol-2-amine hydrobromide (CAS 924848-79-3)
- 4,6-Dimethoxypyrimidine-2-carbaldehyde (CAS 125966-89-4)
- N1,N1-Diisopropyl-3-phenyl-butane-1,4-diamine (CAS 1707357-79-6)
- 2-Phenoxynicotinamide (CAS 111950-69-7)
- N-(5-Methylisoxazol-3-yl)benzamide (CAS 13053-85-5)
- 1-(2-((4-Chlorobenzyl)thio)-4-methylpyrimidin-5-yl)ethan-1-one (CAS 478041-93-9)
- tert-Butyl (3aR,6aS)-3,3-difluorohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate (CAS 2306247-45-8)
- (S)-N-(Pyrrolidin-2-ylmethyl)acetamide (CAS 345347-89-9)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
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