1-(2,4-Difluorobenzyl)piperidin-4-ol CAS 414880-45-8
| CAS No. | 414880-45-8 |
| Molecular Formula | C12H15F2NO |
| Molecular Weight | 227.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,4-Difluorobenzyl)piperidin-4-ol.
CATO supplies 1-(2,4-Difluorobenzyl)piperidin-4-ol (CAS 414880-45-8), a certified reference material (molecular formula C12H15F2NO, MW 227.25 g/mol) for analytical method development and quality control.
The molecular framework of 1-(2,4-Difluorobenzyl)piperidin-4-ol (C12H15F2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(2,4-Difluorobenzyl)piperidin-4-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15F2NO |
| Molecular Weight | 227.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorobenzyl Standards
- N-(2,5-difluorobenzyl)tetrahydro-2H-pyran-4-amine (CAS 1153224-30-6)
- N-(3,5-difluorobenzyl)-1-(tetrahydrofuran-2-yl)methanamine (CAS 1183441-09-9)
- (1-(2,5-Difluorobenzyl)pyrrolidin-3-yl)methanol (CAS 1250270-58-6)
- 3-(2,4-Difluorobenzyl)piperidin-3-ol (CAS 1340204-31-0)
- 3-(2,5-Difluorobenzyl)piperidin-3-ol (CAS 1341505-30-3)
- 4-(2,5-Difluorobenzyl)piperidin-4-ol (CAS 1343735-60-3)
- 3-(2,3-Difluorobenzyl)piperidin-3-ol (CAS 1492232-19-5)
- 1-(3,4-Difluorobenzyl)piperidin-4-ol (CAS 414876-18-9)
Recommended Standards
- 4-Benzyl-6,6-difluoro-1,4-oxazepane (CAS 1934575-12-8)
- 4-(2,6-Difluoro-4-methoxyphenyl)piperidine (CAS 1781511-61-2)
- 1-[(3,4-difluorophenyl)methyl]piperidin-3-ol (CAS 414877-37-5)
- 3-[(2,4-Difluorophenoxy)methyl]piperidine (CAS 946725-02-6)
- 2-Phenylthiomorpholinehydrochloride (CAS 77082-60-1)
- tert-butyl 3-iodopyrrolidine-1-carboxylate (CAS 774234-25-2)
- 6-Methyl-5h-[1,2,4]triazino[5,6-b]indole-3-thiol (CAS 83515-26-8)
- 1-(4-Fluoro-phenyl)-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazine 112767-38-1 8968AC C13H13FN2 (CAS 112767-38-1)
- N-(Furan-2-ylmethyl)morpholine-4-sulfonamide (CAS 833433-60-6)
- Anastrozole Impurity 3 (CAS 120512-37-0)
- Methyl 6-amino-4-methoxyquinoline-2-carboxylate (CAS 169831-76-9)
- 2-Methyl-N-((5-methylthiazol-2-yl)methyl)propan-1-amine dihydrochloride (CAS 1332530-60-5)
- Lenalidomide Impurity 70 (CAS CATO-C4X-190370)
- [His]1-Acetylated Semaglutide (CAS CATO-C4X-2226219)
Why CATO?
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