Bromazepam EP Impurity B CAS 41526-21-0
| CAS No. | 41526-21-0 |
| Molecular Formula | C14H10BrClN2O2 |
| Molecular Weight | 353.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromazepam EP Impurity B.
Bromazepam EP Impurity B (CAS 41526-21-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10BrClN2O2 and a molecular weight of 353.60 g/mol.
Bromazepam EP Impurity B (C14H10BrClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10BrClN2O2 |
| Molecular Weight | 353.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromazepam Standards
Recommended Standards
- 5-[(2E)-2-[(2-bromophenyl)methylidene]hydrazin-1-yl]-2-chlorobenzoic acid (CAS 380215-21-4)
- Trichloro Bisphenol S (CAS 80396-78-7)
- N,N-Diisopropyl-3-(2-methoxy-5-methyl-phenyl)-3-phenylpropylamine-d14 (CAS 1795031-80-9)
- 4-((4-Bromo-2-chlorophenyl)sulfonyl)piperazin-2-one (CAS 1031535-00-8)
- Ibrutinib Impurity 62 (CAS CATO-C4X-106462)
- Benserazide impurity 52 (CAS CATO-C4X-142752)
- Loxoprofen Impurity 29 (CAS CATO-C4X-148829)
- (4-Fluorophenyl)(2-(phenylamino)thiazol-5-yl)methanone (CAS 343376-29-4)
- 2-Allyl-2H-benzo[d][1,2,3]triazole-5-carboxylic acid (CAS 1554297-51-6)
- Bisnortilidine (CAS 53948-51-9)
- 2-(Allyloxy)-4-hydroxybenzaldehyde (CAS 925686-54-0)
- 1-cyclopropyl-2,6-dimethylpiperazine (CAS 1017120-38-5)
- 1-(Aminomethyl)-N,N-dimethylcyclohexan-1-amine dihydrochloride (CAS 41921-99-7)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com