N-Methoxy-N-methyl-6-(trifluoromethyl)nicotinamide CAS 416852-53-4
| CAS No. | 416852-53-4 |
| Molecular Formula | C9H9F3N2O2 |
| Molecular Weight | 234.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-Methoxy-N-methyl-6-(trifluoromethyl)nicotinamide.
N-Methoxy-N-methyl-6-(trifluoromethyl)nicotinamide (CAS 416852-53-4) is a high-purity analytical reference standard with the molecular formula C9H9F3N2O2 and a molecular weight of 234.18 g/mol.
The molecular framework of N-Methoxy-N-methyl-6-(trifluoromethyl)nicotinamide (C9H9F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-Methoxy-N-methyl-6-(trifluoromethyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F3N2O2 |
| Molecular Weight | 234.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-Methoxy-N-methyl-3-(trifluoromethyl)picolinamide (CAS 1211521-63-9)
- N-Methoxy-N-methyl-5-(trifluoromethyl)picolinamide (CAS 1211538-46-3)
- 2-Methoxy-N-(2,2,2-trifluoroethyl)nicotinamide (CAS 1235035-58-1)
- N-Methoxy-N-methyl-2-(trifluoromethyl)nicotinamide (CAS 923288-68-0)
- 1-Methoxy-3-(pentafluoro-λ6-sulfanyl)benzene (CAS 1272542-23-0)
- 2-(2-Methoxy-5-(trifluoromethyl)phenyl)acetic acid (CAS 1000523-82-9)
- Methyl 3-methoxy-5-(trifluoromethyl)benzoate (CAS 1003843-90-0)
- 2-(2-Methoxy-3-(trifluoromethyl)phenyl)acetic acid (CAS 1017778-84-5)
Recommended Standards
- 2052-06-4 Aniline, p-bromo-N,N-diethyl- (8CI) Benzenamine, 4-bromo-N,N-diethyl- p-N,Nddiethylaniline p-Bromo-N,N-diethylaniline 4-Bromo-N,N-diethylaniline EINECS 218-140-8 NSC 8071 N,N-Diethyl-p-bromoaniline (CAS 2052-06-4)
- N-Hydroxy-2-(4-(trifluoromethoxy)phenyl)acetimidamide (CAS 280110-83-0)
- Pyrazoxon (CAS 108-34-9)
- N-hydroxy-2-(3-(trifluoromethyl)phenoxy)acetimidamide (CAS 690632-15-6)
- 5-Bromo-4-chloro-2-nitroaniline (CAS 2091580-55-9)
- Tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-8-azaspiro[4.5]Decane-8-carboxylate (CAS 2304631-46-5)
- 2-((1-Benzyl-1H-indol-3-yl)thio)acetic acid (CAS 524035-97-0)
- 4-Hydroxy-N-despropyl N-tert-Butyloxycarbonyl Ropivacaine (CAS 1391053-93-2)
- 3-((4-(Trifluoromethyl)pyrimidin-2-yl)oxy)aniline (CAS 1216999-17-5)
- (E)-5-(dimethylamino)-1-phenyl-pent-1-en-3-one 5-(Dimethylamino)-1-phenyl-1-penten-3-one 59512-49-1 NSC178847 (CAS 59512-49-1)
- 4-Oxo-1,4-dihydroquinoline-3,6-dicarboxylic acid (CAS 1018060-59-7)
- ((4-Methoxyphenyl)sulfonyl)histidine (CAS 1007971-46-1)
- N-((5-(2-(Trifluoromethyl)phenyl)furan-2-yl)methyl)cyclopropanamine (CAS 1155138-47-8)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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