Nafamostat Impurity 59 CAS 42823-33-6
| CAS No. | 42823-33-6 |
| Molecular Formula | C8H9N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nafamostat Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Nafamostat Impurity 59 (CAS 42823-33-6, C8H9N3O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Nafamostat Impurity 59 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 215.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H9N3O2 HCl |
| Molecular Weight | 215.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nafamostat Standards
- Nafamostat Impurity 61 (CAS 1026613-65-9)
- Nafamostat impurity 110 (CAS 107490-62-0)
- Nafamostat Impurity 65 (CAS 107490-62-0（free base）)
- Nafamostat Impurity N3 (CAS 115325-88-7)
- Nafamostat Impurity 26 (CAS 1192026-58-6)
- Nafamostat Impurity 63 (CAS 121714-82-7)
- Nafamostat Impurity 37 (CAS 122228-09-5)
- Nafamostat Impurity 35 (CAS 130200-58-7)
Recommended Standards
- Azacitidine Impurity 88 (CAS 16491-66-0)
- Peramivir Impurity 49 HCl (CAS 229614-17-9)
- Eltrombopag impurity 151 (CAS CATO-C4X-1198151)
- 2-Ethyl-4-methyl-1H-imidazole-5-carboxylic acid (CAS 84255-25-4)
- 2-Methyl-4-phenyloxazole (CAS 20662-90-2)
- 2-Chloro-4-fluoro-3-methylbenzoic acid, 97% (CAS 173315-54-3)
- Landiolol Impurity 63 (CAS CATO-C4X-263163)
- 2-Amino-4-methyl-1H-pyrrole-3-carboxamide (CAS 1020110-72-8)
- Ethyl 2-(trifluoroacetyl)-3-(N,N-dimethylamino)-2-propenoate (CAS 267243-86-7)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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