2-(Chloromethyl)benzoyl chloride CAS 42908-86-1
| CAS No. | 42908-86-1 |
| Molecular Formula | C8H6Cl2O |
| Molecular Weight | 189.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Chloromethyl)benzoyl chloride (CAS 42908-86-1), molecular formula C8H6Cl2O and molecular weight 189.04 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Chloromethyl)benzoyl chloride (C8H6Cl2O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6Cl2O |
| Molecular Weight | 189.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
Related Chloromethyl Standards
- 4-chloromethyl benzoyl chloride (CAS 876-08-4)
- 2-(Chloromethyl)prop-2-ene-1-sulfonyl chloride (CAS 1909316-27-3)
- 1,2-Bis(chloromethyl)-4-methylbenzene (CAS 2735-06-0)
- 1-Butyl-4-(chloromethyl)cyclohexane (CAS 1097821-01-6)
- 1-(Chloromethyl)-1-pentylcyclopentane (CAS 1466387-25-6)
- 1-(Chloromethyl)-1-isopentylcyclopentane (CAS 1467378-51-3)
- 1-(Chloromethyl)-1-(3,3-dimethylbutyl)cyclobutane (CAS 1481221-05-9)
- (2-(Chloromethyl)-3-methylbutyl)cyclopentane (CAS 1484956-18-4)
Recommended Standards
- 2-(3,4-Dichlorophenyl)oxirane (CAS 52909-94-1)
- 2,3-Dichloroacetophenone (CAS 21886-56-6)
- 2-(3,4-Dichlorophenyl)acetaldehyde (CAS 93467-56-2)
- 2,3-Dichlorobenzimidamide (CAS 769061-91-8)
- Degarelix-d7 Trifluoroacetate (CAS CATO-C4X-21362)
- 3,7-Dimethyl-6,7-dihydro-4H-thiazolo[2,3-c][1,2,4]triazin-4-one (CAS 87450-80-4)
- (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(2-methyl-2H-tetrazol-5-yl)propanoate (CAS 150908-49-9)
- 5-Cyclopropoxy-4-(methylsulfonamido)picolinamide (CAS 1243355-09-0)
- Ethyl 5-(4-fluorophenoxy)pentanoate (CAS 418810-85-2)
- Methyl 2-((3-benzyl-8,9-dimethoxy-2-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio)acetate (CAS 1024018-19-6)
- 1,3-Dicyclohexylimidazole chloride (CAS 181422-72-0)
- Caffeic Acid 3-β-D-Glucoside (CAS 24959-81-7)
- 4-(Chloromethyl)-1-(3-fluoro-2-methylphenyl)-1H-1,2,3-triazole (CAS 1250616-82-0)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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