(3-Chloro-5-(trifluoromethoxy)phenyl)methanol CAS 433926-47-7
| CAS No. | 433926-47-7 |
| Molecular Formula | C8H6ClF3O2 |
| Molecular Weight | 226.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (3-Chloro-5-(trifluoromethoxy)phenyl)methanol (C8H6ClF3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
(3-Chloro-5-(trifluoromethoxy)phenyl)methanol (CAS 433926-47-7), molecular formula C8H6ClF3O2 and molecular weight 226.58 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (3-Chloro-5-(trifluoromethoxy)phenyl)methanol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O2 |
| Molecular Weight | 226.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Acetyl-4-chloro-3-methyl-5-(trifluoromethyl)-1H-pyrazole (CAS 1017793-54-2)
- 2-Chloro-4-ethoxy-6-(trifluoromethyl)pyrimidine (CAS 114963-95-0)
- 2-Chloro-4-(2,2,2-trifluoro-1-hydroxyethyl)phenol (CAS 1250225-28-5)
- 1-Chloro-2-methoxy-4-(trifluoromethoxy)benzene (CAS 1260893-33-1)
- 2-Chloro-1-methoxy-4-(trifluoromethoxy)benzene (CAS 1260893-38-6)
- 4-chloro-2-methoxy-1-(trifluoromethoxy)benzene (CAS 1261450-21-8)
- (2-Chloro-5-trifluoromethoxy-phenyl)-methanol (CAS 1261483-31-1)
- (4-Chloro-2-(trifluoromethoxy)phenyl)methanol (CAS 1261673-90-8)
Recommended Standards
- 5-Chloro-1-ethyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 188689-53-4)
- (S)-5-Chloro-2-(2,2,2-trifluoro-1-hydroxyethyl)phenol (CAS 2227862-41-9)
- 4-Chloro-5-(trifluoromethoxy)benzene-1,2-diamine (CAS 156425-08-0)
- 1-(4-Chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethan-1-one (CAS 808764-27-4)
- n-(3-Chlorobenzyl)-3-ethoxypropan-1-amine (CAS 705955-77-7)
- 2-fluoro-3-hydroxy-5-methylcyclohex-2-en-1-one (CAS 2231677-08-8)
- N-nitroso-colistin a hydrogen methanesulfonate-1 (CAS CATO-C4X-225546)
- Tert-butyl 9-azaspiro[bicyclo[3.3.1]Nonane-3,2'-oxirane]-9-carboxylate (CAS 2219407-47-1)
- Tebipenem Impurity 8 (CAS 161715-27-1)
- Methyl 2,3,5-trichloro-6-hydroxybenzoate (CAS 111217-18-6)
- (Cyclohexadiene)iron tricarbonyl (CAS 12152-72-6)
- n-[(dodecylsulfanyl)({[(4-methoxyphenyl)methyl]amino})methylidene]-3-ethoxypropan-1-amine hydrobromide (CAS 1235441-80-1)
- 1,3-Dihydroisobenzofuran-5-carbonyl chloride (CAS 153967-93-2)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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