4-(Difluoromethyl)-6-methylpyrimidine-2-thiol CAS 438221-08-0
| CAS No. | 438221-08-0 |
| Molecular Formula | C6H6F2N2S |
| Molecular Weight | 176.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-6-methylpyrimidine-2-thiol.
4-(Difluoromethyl)-6-methylpyrimidine-2-thiol (CAS 438221-08-0) is a high-purity analytical reference standard with the molecular formula C6H6F2N2S and a molecular weight of 176.19 g/mol.
Owing to a nitrile group, sulfur-containing functionality, fluorine substitution, an aromatic ring system, 4-(Difluoromethyl)-6-methylpyrimidine-2-thiol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(Difluoromethyl)-6-methylpyrimidine-2-thiol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H6F2N2S |
| Molecular Weight | 176.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Difluoromethyl Standards
- 2-((Difluoromethyl)thio)-4-methylpyrimidine (CAS 129550-03-4)
- 6-[(difluoromethyl)sulfanyl]pyridin-3-amine (CAS 317810-75-6)
- 2-[(difluoromethyl)sulfanyl]phenol (CAS 1251084-72-6)
- ((Difluoromethyl)sulfinyl)benzene (CAS 24933-64-0)
- 2-(difluoromethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1261844-48-7)
- 7a-(Difluoromethyl)tetrahydro-1H-pyrrolo[1,2-a]imidazol-5(6H)-one (CAS 1186533-18-5)
- [1-(difluoromethyl)-3,5-dimethyl-1H-pyrazol-4-yl]methanol (CAS 1341983-71-8)
- 3-(Difluoromethyl)-1-isopropyl-1H-pyrazol-5-ol (CAS 1565935-75-2)
Recommended Standards
- 3,5-Dimethyl-1h-pyrazole-4-sulfonic acid (CAS 89280-34-2)
- 4-Amino-6-fluoro-2-methylquinoline (CAS 288151-49-5)
- 3,4-Dihydro-2H-thiopyran-5-carboxylic acid 1,1-dioxide (CAS 99418-18-5)
- 5-(Aminomethyl)furan-2-sulfonamide (CAS 712256-45-6)
- (4-Heptylphenyl)(quinolin-3-yl)methanone (CAS 1187169-13-6)
- 1(6H)-Pyrimidineacetic acid, 6-oxo-2-phenyl-5-[[(phenylmethoxy)carbonyl]amino]- (CAS 148747-59-5)
- 5-Chloro-2,3-diphenyl-1H-indole (CAS 52598-02-4)
- Tert-butyl ((3-(5-(trifluoromethyl)pyridin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)carbamate (CAS 1160994-72-8)
- 2-((2-Cyclopentylethyl)amino)benzonitrile (CAS 1119389-88-6)
- Mianserin Impurity 109 (CAS 4397-15-3)
- 2,2,2-Trifluoro-1-(pyrazin-2-yl)ethanone (CAS 1147103-48-7)
- 2-Amino-4-bromo-6-fluoro-3-nitrobenzonitrile (CAS 1807698-28-7)
- (11bS)-N-Methyl-N-[(S)-1-phenylethyl]-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine (CAS 712352-04-0)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com