5-Bromo-2-(difluoromethoxy)benzoic acid CAS 438221-79-5
| CAS No. | 438221-79-5 |
| Molecular Formula | C8H5BrF2O3 |
| Molecular Weight | 267.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Bromo-2-(difluoromethoxy)benzoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5-Bromo-2-(difluoromethoxy)benzoic acid (CAS 438221-79-5), a certified reference material (molecular formula C8H5BrF2O3, MW 267.02 g/mol) for analytical method development and quality control.
Structurally, 5-Bromo-2-(difluoromethoxy)benzoic acid (C8H5BrF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 267.02 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-Bromo-2-(difluoromethoxy)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5BrF2O3 |
| Molecular Weight | 267.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 3-Bromo-4-(difluoromethoxy)benzoic acid (CAS 1131615-10-5)
- 3-Bromo-2-(difluoromethoxy)benzoic acid (CAS 1249235-55-9)
- Methyl 5-bromo-4,4,5,5-tetrafluoropentanoate (CAS 1309602-78-5)
- 4-Bromo-3-difluoromethoxybenzoic acid (CAS 1352719-48-2)
- 5-Bromo-2,3-difluoro-4-methoxybenzoic acid (CAS 1780570-14-0)
- 3-Bromo-5,6-difluoro-2-methoxybenzoic acid (CAS 1784368-01-9)
- 4-Bromo-2-(difluoromethoxy)benzoic acid (CAS 553672-25-6)
- 4-Bromo-2-fluoro-1-(3,3,3-trifluoroprop-1-yn-1-yl)benzene (CAS 2137951-06-3)
Recommended Standards
- 4-Iodo-oxazole-5-carboxylic acid ethyl ester (CAS 220580-92-7)
- 5-Iodo-1,3-dimethyl-4-nitro-1H-pyrazole (CAS 85779-99-3)
- 6-Bromo-2,3-difluoro-4-methoxybenzoic acid (CAS 2451903-86-7)
- Ethyl 2-iodooxazole-5-carboxylate (CAS 220580-97-2)
- 1-(4-Methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (CAS 169504-53-4)
- 2-((2,3-Dichlorophenyl)thio)-4-methoxy-6-(trifluoromethyl)pyrimidine (CAS 866039-15-8)
- 3-Cyclopropoxy-5-ethylisonicotinamide (CAS 1243476-31-4)
- Palonosetron Impurity 24 (CAS 83721-32-8)
- Tropicamide Impurity 14 (CAS 50550-65-7)
- (E)-4-((4-Hydroxyphenyl)amino)-4-oxobut-2-enoic acid (CAS 143629-26-9)
- DL-Leucic Acid (CAS 498-36-2)
- 7-bromo-1-benzothiophene-2-carbaldehyde (CAS 19075-47-9)
- 1-(4-(Piperidin-1-ylsulfonyl)phenyl)piperazine (CAS 886506-36-1)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com