[2-(Difluoromethoxy)phenyl]methanethiol CAS 440125-05-3
| CAS No. | 440125-05-3 |
| Molecular Formula | C8H8F2OS |
| Molecular Weight | 190.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 190.21 g/mol gives [2-(Difluoromethoxy)phenyl]methanethiol distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
[2-(Difluoromethoxy)phenyl]methanethiol (CAS 440125-05-3) is a high-purity analytical reference standard with the molecular formula C8H8F2OS and a molecular weight of 190.21 g/mol.
The molecular framework of [2-(Difluoromethoxy)phenyl]methanethiol (C8H8F2OS) is characterized by sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8F2OS |
| Molecular Weight | 190.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluoromethoxy Standards
- [3-(difluoromethoxy)phenyl]methanethiol (CAS 1208074-80-9)
- (4-(Difluoromethoxy)phenyl)methanethiol (CAS 41772-08-1)
- 1-Difluoromethoxy-2,4-dimethyl-3-fluorobenzene (CAS 1803729-32-9)
- 1-Difluoromethoxy-2,4-dimethyl-6-fluorobenzene (CAS 1803838-09-6)
- 1-Difluoromethoxy-3,5-dimethyl-2-fluorobenzene (CAS 1806303-20-7)
- 3-(Difluoromethoxy)-5-methoxypyridin-2-amine (CAS 2848560-94-9)
- 5-(Difluoromethoxy)-2-methoxyphenol (CAS 1261738-91-3)
- 2-(Difluoromethoxy)-5-methoxyphenol (CAS 1261825-52-8)
Recommended Standards
- [3,5-Difluoro-4-(methylsulfanyl)phenyl]methanol (CAS 473299-50-2)
- (2,3-Difluoro-6-methoxyphenyl)(methyl)sulfane (CAS 2386417-90-7)
- 1-(3-(Pyrazin-2-yl)-1H-1,2,4-triazol-5-yl)ethan-1-amine (CAS 958717-43-6)
- (2-((Difluoromethyl)thio)phenyl)methanol (CAS 261944-18-7)
- 2-methoxy-N-[2-(3-methyl-2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]acetamide (CAS 444288-45-3)
- 2-Methylthiazolo[4,5-b]pyrazine (CAS 87444-21-1)
- 4,6-Diethyl-1,4,5,6-tetrahydro-1,3,5-triazin-2-amine (CAS 89910-57-6)
- [2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methanamine (CAS 1048917-47-0)
- 2-Methoxybenzimidamide acetate (CAS 184778-39-0)
- 2-Iodo-1H-pyrrolo[3,2-b]pyridine-5-carboxylic acid (CAS 1260384-51-7)
- 1-cyclopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (CAS 175203-44-8)
- 1-(3,4-Dimethoxyphenyl)hexan-1-one (CAS 52375-87-8)
- (2S,3S,4R,5R,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol (CAS 7282-82-8)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
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