4-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-nitrobenzoic acid CAS 440347-91-1
| CAS No. | 440347-91-1 |
| Molecular Formula | C16H14N2O4 |
| Molecular Weight | 298.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-nitrobenzoic acid.
4-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-nitrobenzoic acid (CAS 440347-91-1), molecular formula C16H14N2O4 and molecular weight 298.29 g/mol, is a CATO reference standard with documented purity and traceability.
4-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-nitrobenzoic acid (C16H14N2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-[3,4-Dihydro-2(1H)-isoquinolinyl]-3-nitrobenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H14N2O4 |
| Molecular Weight | 298.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
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- 2-(3-Chloro-4-fluorophenyl)butan-2-ol (CAS 1379366-86-5)
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- N-benzyl-1-methyl-4-nitro-1H-imidazol-5-amine (CAS 91089-21-3)
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