(2R,4S)-2-(1-Boc-4-fluoro-2-pyrrolidinyl)acetic Acid CAS 441716-22-9
| CAS No. | 441716-22-9 |
| Molecular Formula | C11H18FNO4 |
| Molecular Weight | 247.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (2R,4S)-2-(1-Boc-4-fluoro-2-pyrrolidinyl)acetic Acid (CAS 441716-22-9), a certified reference material (molecular formula C11H18FNO4, MW 247.26 g/mol) for analytical method development and quality control.
Structurally, (2R,4S)-2-(1-Boc-4-fluoro-2-pyrrolidinyl)acetic Acid (C11H18FNO4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 247.26 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H18FNO4 |
| Molecular Weight | 247.26 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropiperidine-2-carboxylic acid (CAS 2165801-50-1)
- 1-(tert-Butyl) 2-methyl (2R,4S)-4-fluoropyrrolidine-1,2-dicarboxylate (CAS 647857-39-4)
- (2R,4R)-1-tert-Butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate (CAS 647857-43-0)
- (2R,5R)-1-[(tert-butoxy)carbonyl]-5-fluoropiperidine-2-carboxylic acid (CAS 2165952-20-3)
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