Vitamin K1 Impurity 67 CAS 4444-14-8
| CAS No. | 4444-14-8 |
| Molecular Formula | C20H39Cl |
| Molecular Weight | 314.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Vitamin K1 Impurity 67 (CAS 4444-14-8, C20H39Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to chlorine substitution, Vitamin K1 Impurity 67 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 314.98 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H39Cl |
| Molecular Weight | 314.98 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
Related Vitamin Standards
- Vitamin K1 Impurity 19 (CAS 2580987-82-0)
- Vitamin K1 Impurity 20 (CAS CATO-C4X-220720)
- Vitamin K1 Impurity 60 (CAS 2580987-83-1)
- Vitamin K1 Impurity 65 (CAS CATO-C4X-220765)
- Vitamin A Impurity 16 (CAS CATO-C4X-218716)
- Vitamin A Impurity 19 (CAS 29443-87-6)
- Vitamin A Acetate (CAS 127-47-9)
- Vitamin B5 Impurity 2 (CAS 5875-50-3)
Recommended Standards
- 4-Bromomethyl-2-fluorobenzeneboronic acid pinacol ester, >96% (CAS 1029439-49-3)
- 2-Bromomethyl-5-fluorobenzeneboronic acid pinacol ester, 96% (CAS 1030832-39-3)
- 2-(5-Bromo-2-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1111096-03-7)
- 4-Bromomethyl-3-fluorobenzeneboronic acid pinacol ester, 97% (CAS 1150271-74-1)
- Pomalidomide Impurity 29 (CAS 504-75-6)
- Tegoprazan Impurity 116 (CAS CATO-C4X-2297116)
- Apixaban Impurity 163 (CAS CATO-C4X-1088163)
- (-)-AkuammicineDISCONTINUED (CAS 639-43-0)
- (R)-Chroman-3-Amine (CAS 59108-53-1)
- (E)-({4-[(4-chlorophenyl)sulfanyl]-3-nitrophenyl}methylidene)[(2,4-dichlorophenyl)methoxy]amine (CAS 477851-88-0)
- 5,5-Dimethyl-2-(naphthalen-1-yl)-1,3-thiazolidine-4-carboxylic acid (CAS 1041100-89-3)
- 2-(4-Methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde (CAS 1255207-13-6)
- 5,6-Dimethylpyrazine-2,3-dicarboxylic acid dihydrate (CAS 41110-52-5)
- Allo-D-Ile17-Tirzepatide (CAS CATO-CPTD788962)
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