2-(Piperazin-1-yl)-4-trifluoromethylbenzonitrile CAS 444583-04-4
| CAS No. | 444583-04-4 |
| Molecular Formula | C12H12F3N3 |
| Molecular Weight | 255.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Piperazin-1-yl)-4-trifluoromethylbenzonitrile (CAS 444583-04-4), molecular formula C12H12F3N3 and molecular weight 255.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Piperazin-1-yl)-4-trifluoromethylbenzonitrile (C12H12F3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(Piperazin-1-yl)-4-trifluoromethylbenzonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H12F3N3 |
| Molecular Weight | 255.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Piperazin Standards
- 4-(Piperazin-1-yl)-2-(trifluoromethyl)benzonitrile (CAS 262295-57-8)
- 5-(Piperazin-1-yl)-2-(pyridin-3-yl)oxazole-4-carbonitrile (CAS 1081136-96-0)
- n-[4-(piperazin-1-yl)phenyl]methanesulfonamide (CAS 125818-94-2)
- 3-(Piperazin-1-yl)pyrrolidine-1-carboxylic Acid tert-Butyl Ester (CAS 867265-71-2)
- 4-(Piperazin-1-yl)benzofuro[3,2-d]pyrimidine (CAS 380339-27-5)
- 3-Piperazin-1-yl-5-(trifluoromethyl)-pyridine-2-carbonitrile (CAS 1987007-72-6)
- 2-Phenyl-6-(piperazin-1-yl)pyridazin-3(2H)-one (CAS 1284410-31-6)
- 6-Phenyl-5-(piperazin-1-yl)pyridazin-3-ol (CAS 132814-16-5)
Recommended Standards
- 2-(4-Fluorophenyl)indolizine-1-carboxylic acid (CAS 477889-04-6)
- 2,2,2-Trifluoro-1-(2-methoxynaphthalen-1-yl)ethan-1-amine (CAS 886370-69-0)
- 2-(4-Fluorophenyl)-1H-indole-4-carboxylic acid (CAS 917614-77-8)
- 2,2,2-Trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-amine (CAS 886370-46-3)
- 2-(4-(Hydroxymethyl)phenyl)propan-2-ol (CAS 88416-58-4)
- n-Methylcyclopropanecarboximidamide (CAS 745758-32-1)
- Ethyl 4-chloro-1,3-dimethyl-1H-pyrazole-5-carboxylate (CAS 119169-63-0)
- 5-Bromopyrimidine-2-sulfonamide (CAS 1339926-29-2)
- N'-(4-Methoxyphenyl)formohydrazide (CAS 35020-01-0)
- 2-(2-Chlorophenyl)-1-((2,6-dichlorobenzyl)oxy)-1H-imidazo[4,5-b]pyridine (CAS 339028-53-4)
- (S)-6-benzyl-2-oxa-5,8-diazaspiro[3.5]Nonan-7-one (CAS 1616761-92-2)
- N-(3-chlorophenyl)-8-methyl-4H-thieno[3,2-c]thiochromene-2-carboxamide (CAS 477887-22-2)
- N-(3-(4-(Dimethylamino)phenyl)propyl)-4-ethoxybenzamide (CAS 953197-19-8)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
Why CATO?
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