(1S)-1-(3,5-Difluorophenyl)ethan-1-amine CAS 444643-16-7
| CAS No. | 444643-16-7 |
| Molecular Formula | C8H9F2N |
| Molecular Weight | 157.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (1S)-1-(3,5-Difluorophenyl)ethan-1-amine (CAS 444643-16-7), a certified reference material (molecular formula C8H9F2N, MW 157.16 g/mol) for analytical method development and quality control.
The molecular framework of (1S)-1-(3,5-Difluorophenyl)ethan-1-amine (C8H9F2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9F2N |
| Molecular Weight | 157.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related S Standards
- N-(3,5-difluorophenyl)-N-ethylamine (CAS 119284-23-0)
- (S)-1-(2,5-Difluorophenyl)ethan-1-amine (CAS 1201363-81-6)
- (R)-1-(2,5-Difluorophenyl)ethan-1-amine (CAS 1212075-49-4)
- (R)-1-(2,6-Difluorophenyl)ethanamine (CAS 1217453-91-2)
- (S)-1-(2,6-difluorophenyl)ethan-1-amine (CAS 1217473-52-3)
- (R)-1-(2,3-Difluorophenyl)ethanamine (CAS 1339886-04-2)
- 2-(2,4-Difluorophenyl)ethanamine (CAS 134672-72-3)
- (S)-1-(2,3-Difluorophenyl)ethanamine (CAS 1415380-62-9)
Recommended Standards
- 2-Ethyl-4,5-difluoroaniline (CAS 1849300-55-5)
- (2,3-Difluoro-4-methylphenyl)methanamine (CAS 261763-41-1)
- 4-(Difluoromethyl)-3,5-dimethylpyridine (CAS 1805311-30-1)
- (2,4-Difluoro-5-methylphenyl)methanamine (CAS 329314-63-8)
- 4-isopropoxy-N1,N1-dimethylisophthalamide (CAS CATO-C3D-263041)
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- Methyl 2-(3-oxo-3H-indol-2-yl)hydrazinecarbodithioate (CAS 59224-26-9)
- Tert-butyl hexyl(2-hydroxyethyl)carbamate (CAS 475569-21-2)
- Thiorphan-d7 (CAS 1276297-68-7)
- 4-Chloro-2,2,6,6-tetramethylpiperidine hydrochloride (CAS 5382-35-4)
- 1,1,1,5,5,5-hexafluoro-3-[(phenylamino)methylidene]pentane-2,4-dione (CAS 142503-36-4)
- Ethyl 5-tert-butyl-1,2,4-oxadiazole-3-carboxylate (CAS 158154-63-3)
- 3-(Cyanomethyl)-5-(trifluoromethoxy)benzoic acid (CAS 2648588-70-7)
- Allo-Thr7-Tirzepatide (CAS CATO-CPTD788933)
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