(2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-chloro-5-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate CAS 4451-37-0
| CAS No. | 4451-37-0 |
| Molecular Formula | C12H17ClO8 |
| Molecular Weight | 324.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-chloro-5-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate.
(2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-chloro-5-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate (CAS 4451-37-0), molecular formula C12H17ClO8 and molecular weight 324.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-chloro-5-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate (C12H17ClO8) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H17ClO8 |
| Molecular Weight | 324.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
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