2-((3-Cyano-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide CAS 445382-44-5
| CAS No. | 445382-44-5 |
| Molecular Formula | C19H17F3N4O2S |
| Molecular Weight | 422.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((3-Cyano-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide.
2-((3-Cyano-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide (CAS 445382-44-5), molecular formula C19H17F3N4O2S and molecular weight 422.42 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 2-((3-Cyano-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 422.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-((3-Cyano-6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)thio)-N-(4-(trifluoromethoxy)phenyl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H17F3N4O2S |
| Molecular Weight | 422.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Cyano Standards
- (R)-4-Cyano-N-(1-(1-ethyl-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide (CAS 1025506-51-7)
- N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-2-[[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]thio]acetamide (CAS 625369-63-3)
- O-(3-Cyano-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2-yl) O,O-diethyl phosphorothioate (CAS 286435-85-6)
- 2-((3-Cyano-5,6,7,8,9,10-hexahydrocycloocta[b]pyridin-2-yl)thio)-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)acetamide (CAS 488725-33-3)
- N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-((3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-yl)thio)acetamide (CAS 443120-81-8)
- N-((2-Cyano-4-(neopentylamino)pyrimidin-5-yl)methyl)-4-(4-methylpiperazin-1-yl)benzamide (CAS 501000-36-8)
- 2-((3-Cyano-4,6-diphenylpyridin-2-yl)thio)-N-phenylacetamide (CAS 332040-65-0)
- Methyl 4-((1-((4-cyano-3-(trifluoromethyl)phenyl)amino)-2-methyl-1-oxopropan-2-yl)amino)-2-fluorobenzoate (CAS 208122-09-2)
Recommended Standards
- (3,5-Dimethyl-4-((phenylsulfonyl)methyl)-1H-pyrazol-1-yl)(3-(trifluoromethyl)phenyl)methanone (CAS 324009-24-7)
- 2-((5-(2-Methoxyphenyl)-4-methyl-4h-1,2,4-triazol-3-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 333312-63-3)
- 2-(3,4-Dimethoxyphenyl)-4-methyl-N-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxamide (CAS 400080-52-6)
- Ceftizoxime Impurity 47 (CAS CATO-C4X-179347)
- EG 00229 (CAS 1018927-63-3)
- 4-(4-(tert-Butyl)cyclohexylidene)-2-phenyloxazol-5(4H)-one (CAS 93832-76-9)
- Nickel(II) Carbonate Basic Tetrahydrate,99.00% (CAS 39430-27-8)
- 4,4-oxydipiperidine (CAS 1951442-07-1)
- Ethyl 2-hydroxy-6-nitrobenzoate (CAS 1261477-56-8)
- 6-(Bromomethyl)pyridin-2(1H)-one (CAS 1227563-72-5)
- Benzyl 5-bromopyridin-3-ylcarbamate (CAS 762298-10-2)
- 3,3,3-Trifluoro-2-(5-methyl-1h-indol-3-yl)propanoic acid (CAS 252729-38-7)
- Shield 1 (CAS 914805-33-7)
- D-Lys16-Tirzepatide (CAS CATO-CPTD788918)
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