Ethyl 4-cyano-5-(2-{[3-cyano-6-methyl-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]sulfanyl}acetamido)-3-methylthiophene-2-carboxylate CAS 445383-37-9
| CAS No. | 445383-37-9 |
| Molecular Formula | C25H23N5O3S3 |
| Molecular Weight | 537.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl 4-cyano-5-(2-{[3-cyano-6-methyl-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]sulfanyl}acetamido)-3-methylthiophene-2-carboxylate (C25H23N5O3S3) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Ethyl 4-cyano-5-(2-{[3-cyano-6-methyl-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]sulfanyl}acetamido)-3-methylthiophene-2-carboxylate (CAS 445383-37-9), a certified reference material (molecular formula C25H23N5O3S3, MW 537.68 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4-cyano-5-(2-{[3-cyano-6-methyl-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]sulfanyl}acetamido)-3-methylthiophene-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H23N5O3S3 |
| Molecular Weight | 537.68 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 3 |
Related Ethyl Standards
- 2-((3-Cyano-4-(4-methoxyphenyl)-6-phenylpyridin-2-yl)thio)-N,N-dicyclohexylacetamide (CAS 332101-03-8)
- 2-((3-Cyano-4-(3,4-dimethoxyphenyl)-6-phenylpyridin-2-yl)thio)-N-(2-methyl-4-nitrophenyl)acetamide (CAS 332177-59-0)
- 2-((3-Cyano-4-(3,4-dimethoxyphenyl)-6-phenylpyridin-2-yl)thio)-N-(2-methyl-5-nitrophenyl)acetamide (CAS 444152-30-1)
- 2-((3-Cyano-4-(4-ethoxy-3-methoxyphenyl)-6-phenylpyridin-2-yl)thio)-N-(4-nitrophenyl)acetamide (CAS 332162-69-3)
- 2-((3-Cyano-6-(4-ethoxyphenyl)-4-phenylpyridin-2-yl)thio)-N-(4-methoxy-2-nitrophenyl)acetamide (CAS 444152-73-2)
- 2-((3-Cyano-4-(4-methoxyphenyl)-6-(p-tolyl)pyridin-2-yl)thio)-N,N-diphenylacetamide (CAS 332114-45-1)
- Ethyl 2-(2-((3-cyano-4-phenyl-6-(p-tolyl)pyridin-2-yl)thio)acetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 332053-33-5)
- Ethyl 2-(2-((3-cyano-6-phenyl-4-(p-tolyl)pyridin-2-yl)thio)acetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 332161-68-9)
Recommended Standards
- NH-bis(PEG3-Boc) (CAS 1814901-03-5)
- alfa-Tauromuricholic Acid Sodium Salt (CAS 25613-05-2（free base）)
- 3,5,9-Trioxa-4-phosphapentacosan-1-aminium,7- -4-hydroxy-N,N,N-trimethyl-10-oxo-,innersalt,4-oxide,(7R] 79512-78-0 (CAS 79512-78-0)
- Ulipristal Related Compound A (CAS 730962-28-4)
- 2-[4-(2-methoxyphenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl]acetic acid (CAS 1152641-90-1)
- 3-Bromo-6-difluoromethoxy-2-nitrotoluene (CAS 1807244-56-9)
- 4-Bromo-5-(trifluoromethoxy)quinoline (CAS 1823484-29-2)
- Nifuratel Impurity 29 (CAS 698-63-5)
- 5-Cyano-4-hydroxyquinazoline (CAS 1260658-66-9)
- Methyl 2,6-bis(benzyloxy)benzoate (CAS 25983-51-1)
- 4-Methylvaleryl Chloride (CAS 38136-29-7)
- 3-Fluoro-4-((trifluoromethyl)thio)benzoic acid (CAS 1208080-44-7)
- Milnacipran impurity 36 (CAS 1237261-60-7)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
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