7-Methoxy-3-(trifluoromethyl)quinoxalin-2(1h)-one CAS 445498-40-8
| CAS No. | 445498-40-8 |
| Molecular Formula | C10H7F3N2O2 |
| Molecular Weight | 244.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 7-Methoxy-3-(trifluoromethyl)quinoxalin-2(1h)-one (CAS 445498-40-8), a certified reference material (molecular formula C10H7F3N2O2, MW 244.17 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 7-Methoxy-3-(trifluoromethyl)quinoxalin-2(1h)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 244.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7F3N2O2 |
| Molecular Weight | 244.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methoxy Standards
- 6-Methoxy-2-(trifluoromethyl)-1,5-naphthyridin-4-ol (CAS 1565779-83-0)
- 2-Methoxy-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzaldehyde (CAS 205485-25-2)
- 6-methoxy-2-(trifluoromethyl)-1,4-dihydroquinazolin-4-one (CAS 301233-15-8)
- 6-Methoxy-4-(trifluoromethyl)quinazolin-2(1H)-one (CAS 214288-03-6)
- 7-Methoxy-2-(trifluoromethyl)-4H-chromen-4-one (CAS 578-84-7)
- 7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-4-carbaldehyde (CAS 909718-83-8)
- 7-Methoxy-4-(trifluoromethyl)coumarin, 98% (CAS 575-04-2)
- 8-Methoxy-2-(trifluoromethyl)quinazolin-4(1H)-one (CAS 640297-55-8)
Recommended Standards
- 7-Methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 874830-65-6)
- 7-Hydroxy-8-methyl-4-(trifluoromethyl)-2H-chromen-2-one (CAS 82747-40-8)
- 7-(Hydroxymethyl)-3-(trifluoromethyl)quinoxalin-2(1H)-one (CAS 2589532-89-6)
- 8-Methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 874776-53-1)
- 1-Methyl-1,2,3,4-tetrahydroisoquinoline (CAS 4965-09-7)
- (R)-3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid (CAS 791582-16-6)
- (S)-2-((Diphenylphosphoryl)amino)propanoic acid (CAS 62056-87-5)
- Z-Neticonazole (CAS 138206-84-5)
- 5-Chloro-1-(4-methoxyphenyl)pentan-1-one (CAS 949-06-4)
- 3-(5-Methyl-[1,3,4]oxadiazol-2-yl)-5-trifluoromethylphenylamine (CAS 1683551-66-7)
- 2-iodanyl-3-methyl-pyridine 2-iodo-3-methylpyridine 22282-58-2 A816084 (CAS 22282-58-2)
- 1-Ethyl-N-((4-methylthiazol-5-yl)methyl)-1h-pyrazol-4-amine (CAS 1485729-54-1)
- 2-(Tert-butyl) 5-methyl (1S,4R,5S)-2-azabicyclo[2.2.1]Heptane-2,5-dicarboxylate (CAS 2381814-56-6)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com