2-Fluoro-6-(hydroxymethyl)phenol CAS 446-58-2
| CAS No. | 446-58-2 |
| Molecular Formula | C7H7FO2 |
| Molecular Weight | 142.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Fluoro-6-(hydroxymethyl)phenol.
2-Fluoro-6-(hydroxymethyl)phenol (CAS 446-58-2) is a high-purity analytical reference standard with the molecular formula C7H7FO2 and a molecular weight of 142.13 g/mol.
The molecular framework of 2-Fluoro-6-(hydroxymethyl)phenol (C7H7FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Fluoro-6-(hydroxymethyl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7FO2 |
| Molecular Weight | 142.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 5-Fluoro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (CAS 1041170-80-2)
- 5-Fluoro-3-methoxypyridin-2-amine (CAS 1097264-90-8)
- 4-Fluoro-3-methoxyphenol (CAS 117902-15-5)
- 2-Fluoro-5-methoxyphenol (CAS 117902-16-6)
- 5-Fluoro-2-methoxypyridin-3-amine (CAS 1211541-93-3)
- 3-Fluoro-5-methoxypyridin-2-amine (CAS 1211589-70-6)
- 2-Fluoro-5-methoxypyridin-4-amine (CAS 1227571-74-5)
- 2-Fluoro-5-methoxypyridin-3-amine (CAS 1227581-69-2)
Recommended Standards
- 2-Fluoro-4-hydroxybenzenemethanol (CAS 96740-92-0)
- 3-Amino-5-fluoro-6-methoxypyridine (CAS 886372-63-0)
- 2-Fluoro-4-(hydroxymethyl)phenol (CAS 96740-93-1)
- 3-Fluoro-2-(hydroxymethyl)phenol (CAS 660390-77-2)
- (S)-N-Cyclohexyl-N-(3-methylbenzyl)pyrrolidin-3-amine (CAS 820980-51-6)
- Quinoxaline-5-thiol (CAS 760121-40-2)
- 1-Ethyl-2-ethynyl-1h-imidazole (CAS 1339042-77-1)
- Tert-butyl n-[(n'-hydroxycarbamimidoyl)(2-methoxyphenyl)methyl]carbamate (CAS 1306615-56-4)
- 3H-Phenoxazin-3-one (CAS 1916-63-8)
- 2-Chloro-1-fluoro-3-(trifluoromethyl)benzene (CAS 1099597-97-3)
- 3-Cyclobutyl-4-ethyl-1h-pyrazol-5-amine (CAS 1187561-32-5)
- 2,4-Bis-(1-phenylethyl)phenol (CAS 2769-94-0)
- [(1R,2S)-2-aminocyclohexyl]methanol (CAS 213764-26-2)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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