4-Nitrobenzoyl isocyanate CAS 4461-37-4
| CAS No. | 4461-37-4 |
| Molecular Formula | C8H4N2O4 |
| Molecular Weight | 192.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Nitrobenzoyl isocyanate (C8H4N2O4) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-Nitrobenzoyl isocyanate (CAS 4461-37-4), molecular formula C8H4N2O4 and molecular weight 192.13 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Nitrobenzoyl isocyanate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4N2O4 |
| Molecular Weight | 192.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Nitrobenzoyl Standards
- 3-Nitrobenzoyl isocyanate (CAS 5843-49-2)
- 3-nitrobenzoyl chloride (CAS 121-90-4)
- 4-Nitrobenzoyl-d4 Chloride (CAS 171777-67-6)
- O-(4-Nitrobenzoyl)hydroxylamine 35657-36-4 MFCD11976095 SY029700 (CAS 35657-36-4)
- 4-Nitrobenzoyl Chloride (CAS 122-04-3)
- 4-Methyl-3-nitrobenzoyl chloride (CAS 10397-30-5)
- 2-Methyl-3-nitrobenzoyl chloride (CAS 39053-41-3)
- 3-Methyl-2-nitrobenzoyl chloride (CAS 50424-93-6)
Recommended Standards
- 4-Cyano-2-nitrobenzoic Acid (CAS 64629-99-8)
- 4-Nitroindoline-2,3-dione (CAS 61394-93-2)
- 4-Nitrophthalimide (CAS 89-40-7)
- 3-Cyano-5-nitrobenzoic acid (CAS 98556-65-1)
- 2-[(4-methylphenyl)amino]benzoic acid (CAS 16524-23-5)
- 3-(3-Iodophenyl)-1-methyl-1h-pyrazol-5-amine (CAS 1152665-65-0)
- 4-Bromo-6-chloro-2-methylquinoline (CAS 1070879-50-3)
- Pyridinium, 1-(2-hydroxyethyl)-, chloride (CAS 34941-69-0)
- 3-(2,4-Difluorophenyl)-2,2-dimethylpropan-1-amine (CAS 1492445-11-0)
- Ethyl cis-2-Isothiocyanato-1-Cyclohexanecarboxylate (CAS 336185-30-9)
- 2-Amino-3-(trifluoromethyl)cyclopropane-1-carboxylic acid (CAS 1240526-67-3)
- 1-Benzyl-1-[4-(trifluoromethyl)benzyl]hydrazine dihydrochloride (CAS 237403-61-1)
- Selenosemicarbazide (CAS 21198-79-8)
- Liraglutide Impurity 22 (CAS 536721-25-2)
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