Doxepin Hydrochloride EP Impurity A CAS 4504-87-4
| CAS No. | 4504-87-4 |
| Molecular Formula | C14H10O2 |
| Molecular Weight | 210.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C14H10O2, Doxepin Hydrochloride EP Impurity A contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 210.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Doxepin Hydrochloride EP Impurity A (CAS 4504-87-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H10O2 and a molecular weight of 210.23 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10O2 |
| Molecular Weight | 210.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Doxepin Standards
- Doxepin Impurity 7 (CAS 21324-99-2)
- Doxepin Impurity N1 (CAS 866996-44-3)
- Doxepin EP Imp C(Desmethyldoxepine)(USP (CAS 1225-56-5)
- Doxepin Hydrochloride - Impurity C (Freebase) (CAS 67035-76-1)
- Doxepin EP Impurity D (CAS 3607-18-9)
- (E)-Doxepin (CAS 3607-34-9)
- Doxepin (CAS CATO-C4X-122615)
- Doxepin-D (CAS 138387-16-3)
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