2-Fluorophenylacetylchloride CAS 451-81-0
| CAS No. | 451-81-0 |
| Molecular Formula | C8H6ClFO |
| Molecular Weight | 172.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 172.58 g/mol gives 2-Fluorophenylacetylchloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-Fluorophenylacetylchloride (CAS 451-81-0), a certified reference material (molecular formula C8H6ClFO, MW 172.58 g/mol) for analytical method development and quality control.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2-Fluorophenylacetylchloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 172.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Fluorophenylacetylchloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO |
| Molecular Weight | 172.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Recommended Standards
- 2-Fluoro-4-methylbenzoyl chloride (CAS 59189-98-9)
- 3’-Chloro-4’-fluoroacetophenone (CAS 2923-66-2)
- 2-Chloro-3-(fluoromethyl)benzaldehyde (CAS 916791-72-5)
- 3'-Chloro-2-Fluoro-Acetophenone (CAS 90221-70-8)
- 2-hydroxy-N-(pyridin-2-ylmethyl)propanamide (CAS 1267182-36-4)
- m-PEG4-SH (CAS 52190-55-3)
- 5-Bromo-3-nitro-1H-indole (CAS 1260655-97-7)
- 1,5-Dibromo-2-methyl-3-nitrobenzene (CAS 67365-46-2)
- 1,3-Benzenedicarboxylic acid, polymer with 1-amino-2-propanol and 1,4-cyclohexanedimethanol (CAS 125304-12-3)
- (5-(4-Fluorophenyl)-1H-1,2,4-triazol-3-yl)(3-methoxyphenyl)methanamine (CAS 1708370-94-8)
- Methyl (Z)-(3-bromo-4-methyl-5-oxofuran-2(5H)-ylidene)ethanoate (CAS 1451878-28-6)
- 1,2-Dibromo-3-fluoro-4-iodo-benzene (CAS 881667-35-2)
- Mexiletine Impurity N5 (CAS 117322-90-4)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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