2,4-Difluorobenzyl Chloride CAS 452-07-3
| CAS No. | 452-07-3 |
| Molecular Formula | C7H5ClF2 |
| Molecular Weight | 162.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,4-Difluorobenzyl Chloride.
2,4-Difluorobenzyl Chloride (CAS 452-07-3), molecular formula C7H5ClF2 and molecular weight 162.56 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to fluorine/chlorine substitution, an aromatic ring system, 2,4-Difluorobenzyl Chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 162.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2,4-Difluorobenzyl Chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF2 |
| Molecular Weight | 162.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Difluorobenzyl Standards
- 2,6-Difluorobenzyl Chloride (CAS 697-73-4)
- 3,5-Difluorobenzyl Chloride (CAS 220141-71-9)
- o-(2,5-Difluorobenzyl)hydroxylamine (CAS 1388030-23-6)
- o-(2,3-Difluorobenzyl)hydroxylamine (CAS 1388036-03-0)
- N-(2,3-Difluorobenzyl)hydroxylamine (CAS 1548551-64-9)
- N-(3,5-Difluorobenzyl)hydroxylamine (CAS 1697936-47-2)
- O-(3,4-difluorobenzyl)hydroxylamine (CAS 628703-31-1)
- O-(3,5-Difluorobenzyl)hydroxylamine (CAS 796061-03-5)
Recommended Standards
- 1-Chloro-4,5-difluoro-2-methylbenzene (CAS 252936-45-1)
- 1-Chloro-4-(difluoromethyl)benzene (CAS 43141-66-8)
- 2-Chloro-1,4-difluoro-3-methylbenzene (CAS 90292-64-1)
- 1-Chloro-2,5-difluoro-4-methylbenzene (CAS 879093-04-6)
- Methyl (R)-2-(1-((2-aminopyridin-3-yl)oxy)ethyl)-4-fluorobenzoate (CAS 1454847-99-4)
- 2,5-Dimethylthiophene-3-sulfonamide (CAS 140646-60-2)
- 3-(4-Methylbenzyl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxylic acid (CAS 951547-65-2)
- 3-(Difluoromethyl)-6-(trifluoromethyl)pyridine-2,4-diamine (CAS 1804696-70-5)
- 73571-20-7 Pyridine, 3-methyl-5-phenoxy- (CAS 73571-20-7)
- 2-((5-(N,N-Dimethylsulfamoyl)-2-methylphenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 380176-64-7)
- (Hydroxymethyl)benzenesulfonic acid (CAS 927667-93-4)
- N,N,5,5-tetramethyl-1,3-dioxan-2-amine (CAS 62999-86-4)
- 3-Cyclohexyl-5-((2,4-dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazole (CAS 332872-97-6)
- Peptide Impurity 28 (CAS 1350456-64-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com