2-Fluoro-5-nitroanisole CAS 454-16-0
| CAS No. | 454-16-0 |
| Molecular Formula | C7H6FNO3 |
| Molecular Weight | 171.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-Fluoro-5-nitroanisole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-Fluoro-5-nitroanisole (CAS 454-16-0), molecular formula C7H6FNO3 and molecular weight 171.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Fluoro-5-nitroanisole (C7H6FNO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H6FNO3 |
| Molecular Weight | 171.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
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Recommended Standards
- 2-Fluoro-5-methyl-4-nitrophenol (CAS 63762-80-1)
- 2-Fluoro-6-nitroanisole (CAS 484-94-6)
- 2-Fluoro-4-nitrobenzyl Alcohol (CAS 660432-43-9)
- 2-Fluoro-N,6-dihydroxybenzamide (CAS 855996-64-4)
- Tetrabutylammonium 4-methylbenzenesulfonate (CAS 7182-86-7)
- 5-(3,5-Dimethylphenyl)pyrimidin-2-ol (CAS 1111108-38-3)
- (r)-3-Amino-3-(anthracen-2-yl)propanenitrile (CAS 1213528-51-8)
- Methyl 4-(4-(trifluoromethyl)pyridin-2-yl)benzoate (CAS 1299607-44-5)
- 1,2-Dibromo-4-(trifluoromethoxy)benzene (CAS 1682-06-0)
- 1-(2-Methoxy-5-nitrophenyl)-1H-pyrrole-2-carbaldehyde (CAS 383136-08-1)
- 3-Bromo-5-((tetrahydro-2H-pyran-4-yl)methoxy)pyridine (CAS 1135041-76-7)
- 5,6,7,8-Tetrahydroquinoline-8-carbonitrile hydrochloride (CAS 60169-77-9)
- 6-(Methylamino)-3,4-dihydronaphthalen-1(2H)-one (CAS 31435-76-4)
- His-Aib-Semaglutide (CAS CATO-C4X-2226220)
Why CATO?
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