4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid CAS 45654-48-6
| CAS No. | 45654-48-6 |
| Molecular Formula | C3H2N2O3S |
| Molecular Weight | 146.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid (C3H2N2O3S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid (CAS 45654-48-6), molecular formula C3H2N2O3S and molecular weight 146.12 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C3H2N2O3S |
| Molecular Weight | 146.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1970 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 4-Fluorophthalonitrile (CAS 65610-14-2)
- 5-Fluoroisophthalonitrile (CAS 453565-55-4)
- 3-Fluorophthalonitrile (CAS 65610-13-1)
- 5-Nitrothiazol-2(3H)-one (CAS 3034-49-9)
- 2-Amino-4-(bromomethyl)-5-(difluoromethyl)nicotinaldehyde (CAS 1805345-66-7)
- 2,6-Difluorobenzoic-d3 Acid (CAS 1219804-21-3)
- tert-Butyl ((1r,4r)-4-(cyclopropylamino)cyclohexyl)carbamate (CAS 1695112-92-5)
- (3,7-Dimethyl-1H-indol-2-yl)methanol (CAS 706788-99-0)
- 3-Amino-3-(1,3-thiazol-4-yl)propanoic acid (CAS 1311403-32-3)
- Cinacalcet Impurity 42 (CAS 3906-16-9)
- 2-(aminomethyl)-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one (CAS 1072876-01-7)
- 4-(methoxymethyl)thiophene-2-carbaldehyde (CAS 54796-48-4)
- Benzyl (S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylate (CAS 223785-66-8)
- [Ser]8-Acetylated Semaglutide (CAS CATO-C4X-2226218)
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