Celecoxib Impurity N5 CAS 457639-26-8
| CAS No. | 457639-26-8 |
| Molecular Formula | C18H16F3N3O2S |
| Molecular Weight | 395.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Celecoxib Impurity N5 (CAS 457639-26-8, C18H16F3N3O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Celecoxib Impurity N5 (C18H16F3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Celecoxib Impurity N5 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H16F3N3O2S |
| Molecular Weight | 395.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Celecoxib Standards
- Celecoxib USP Related Compound C (CAS 170570-09-9)
- Celecoxib Impurity 17 (CAS 2247197-66-4)
- Celecoxib Hydroxymethyl Analog (CAS 17571-00-3)
- Celecoxib Impurity 30 (CAS 2356153-95-0)
- Celecoxib Impurity 31 (CAS CATO-C4X-104331)
- Celecoxib Impurity 68 (CAS 170569-91-2)
- Celecoxib Impurity 7(Hydroxy Celecoxib) (CAS 170571-00-3)
- Celecoxib Impurity 41 (CAS 1803258-57-2)
Recommended Standards
- 2-(3-Cyclopropyl-6-(5-ethylthiophen-2-yl)-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 937606-22-9)
- 4-Imino-6,7-dimethoxy-3-{[3-(trifluoromethyl)phenyl]methyl}-1,2,3,4-tetrahydroquinazoline-2-thione (CAS 439093-83-1)
- (2R,3S,4R,5R,6S)-5-acetamido-6-(benzyloxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diyl diacetate (CAS 33401-01-3)
- 5-(3,4-Dimethoxybenzyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol (CAS 883019-83-8)
- GST-HG171 Impurity 3 (CAS CATO-C4X-30603)
- Gatifloxacin Impurity 27 (CAS CATO-C4X-125327)
- Sulbactam Impurity 41 (CAS CATO-C4X-175641)
- N-(3-((3-(dimethylamino)propyl)amino)propyl)nicotinamide (CAS 404013-89-4)
- 3-(5-Hydroxy-1H-indol-3-yl)-2-(2-((6-oxo-6H-benzo[c]chromen-3-yl)oxy)propanamido)propanoic acid (CAS 1214864-54-6)
- 1-(5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3,5-dimethylphenyl)methanimine (CAS 956612-26-3)
- THZ1-R, >98% (HPLC) (CAS 1621523-07-6)
- 2-Hydroxy-4-Nitroaniline (CAS 121-88-0)
- Olmesartan impurity 88 (CAS CATO-C4X-109788)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com