1-(2,3-Dichloroquinoxalin-5-yl)ethanone CAS 459835-98-4
| CAS No. | 459835-98-4 |
| Molecular Formula | C10H6Cl2N2O |
| Molecular Weight | 241.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,3-Dichloroquinoxalin-5-yl)ethanone.
1-(2,3-Dichloroquinoxalin-5-yl)ethanone (CAS 459835-98-4), molecular formula C10H6Cl2N2O and molecular weight 241.07 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(2,3-Dichloroquinoxalin-5-yl)ethanone (C10H6Cl2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6Cl2N2O |
| Molecular Weight | 241.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloroquinoxalin Standards
- N-(2,3-Dichloroquinoxalin-6-yl)acetamide (CAS 112928-26-4)
- 6,7-Dichloroquinoxalin-2(1H)-one (CAS 78470-95-8)
- 2,3-Dichloroquinoxalin-6-amine (CAS 76089-01-5)
- 3,7-Dichloroquinoxalin-2-amine (CAS 89978-29-0)
- 6,7-Dichloroquinoxalin-2-amine (CAS 76002-68-1)
- 2-((3,6-Dichloroquinoxalin-2-yl)amino)propan-1-ol (CAS 1217300-57-6)
Recommended Standards
- (4-(Azetidin-1-ylsulfonyl)phenyl)boronic acid (CAS 871329-68-9)
- 1-(2,5-Dichlorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 98949-18-9)
- (3,4-Dichlorophenyl)(furan-2-yl)methanone (CAS 52192-59-3)
- 1-(3,4-Dichlorophenyl)-1H-pyrazole-4-carbaldehyde (CAS 445302-83-0)
- tert-Butyl (2-bromo-4-chlorophenyl)carbamate (CAS 384793-16-2)
- 3-(2-Bromothiazol-4-yl)benzonitrile (CAS 887625-64-1)
- [1-(2-phenylethyl)-1h-1,2,3-triazol-4-yl]methanol (CAS 1247587-06-9)
- 5-Methyl-3-phenyl-2,3-dihydrobenzofuran (CAS 111864-81-4)
- 3-Cyclopropoxy-5-nitropicolinonitrile (CAS 1243467-94-8)
- Ethyl (S)-2-amino-5-ureidopentanoate hydrochloride (CAS 93964-75-1)
- Methyl 2-(4-bromo-3-methoxyphenyl)acetate (CAS 203805-73-6)
- 4-Butoxy-1-naphthaldehyde (CAS 54784-10-0)
- (4-(1H-pyrrol-1-yl)phenyl)(4-phenylpiperazin-1-yl)methanone (CAS 439097-45-7)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
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