Oxytetracycline EP impurity F(Anhydrooxytetracycline) CAS 4660-26-8
| CAS No. | 4660-26-8 |
| Molecular Formula | C22H22N2O8 |
| Molecular Weight | 442.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Oxytetracycline EP impurity F(Anhydrooxytetracycline) (CAS 4660-26-8), a pharmacopoeial impurity reference standard (molecular formula C22H22N2O8, MW 442.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Oxytetracycline EP impurity F(Anhydrooxytetracycline) (C22H22N2O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Oxytetracycline EP impurity F(Anhydrooxytetracycline) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22N2O8 |
| Molecular Weight | 442.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Oxytetracycline Standards
- Oxytetracycline EP Impurity D (CAS 18695-01-7)
- Oxytetracycline EP Impurity E (CAS 18751-99-0)
- Oxytetracycline EP Impurity B (CAS 60-54-8)
- Oxytetracycline impurity 9 (CAS CATO-C4X-20139)
- Oxytetracycline EP Impurity C (CAS 7647-65-6)
- Oxytetracycline Hemicalcium Salt (CAS 15251-48-6)
- Oxytetracycline EP Impurity A (CAS 14206-58-7)
- Oxytetracycline-d6 (CAS CATO-CCAD303668)
Recommended Standards
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