5-Chloromethyl-2-(4-(trifluoromethyl)-phenyl)-1H-imidazole CAS 466664-94-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloromethyl-2-(4-(trifluoromethyl)-phenyl)-1H-imidazole.

5-Chloromethyl-2-(4-(trifluoromethyl)-phenyl)-1H-imidazole (CAS 466664-94-8) is a high-purity analytical reference standard with the molecular formula C11H8ClF3N2 and a molecular weight of 260.64 g/mol.

The molecular framework of 5-Chloromethyl-2-(4-(trifluoromethyl)-phenyl)-1H-imidazole (C11H8ClF3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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