2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one CAS 473565-63-8

Purity 97%+In StockPharmaceutical Standards
CAS No.473565-63-8
Molecular FormulaC11H9Cl3O4
Molecular Weight311.55 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one CAS 473565-63-8 chemical structure

Description

The occurrence of 2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one (CAS 473565-63-8), molecular formula C11H9Cl3O4 and molecular weight 311.55 g/mol, is a CATO reference standard with documented purity and traceability.

2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one (C11H9Cl3O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC11H9Cl3O4
Molecular Weight311.55 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Halogen ContentCl-containing

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