6,7-Dihydroxyisobenzofuran-1(3H)-one CAS 4741-57-5
| CAS No. | 4741-57-5 |
| Molecular Formula | C8H6O4 |
| Molecular Weight | 166.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6,7-Dihydroxyisobenzofuran-1(3H)-one (CAS 4741-57-5) is a high-purity analytical reference standard with the molecular formula C8H6O4 and a molecular weight of 166.13 g/mol.
The molecular framework of 6,7-Dihydroxyisobenzofuran-1(3H)-one (C8H6O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6O4 |
| Molecular Weight | 166.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Dihydroxyisobenzofuran Standards
Recommended Standards
- 6,7-Dihydroxy-benzofuran-3-one (CAS 6272-27-1)
- 6-Carbamoylnicotinic acid (CAS 886590-61-0)
- 6,7-Dihydro-[1,4]dioxino[2,3-c]pyridazine-3-carbaldehyde (CAS 943026-42-4)
- 6-Carbamoylpyridine-2-carboxylic acid (CAS 97310-93-5)
- 3-Methyl-8-azaspiro[4.5]Decan-1-one hydrochloride (CAS 2055841-72-8)
- Ethyl 4-((2-methylbenzyl)amino)quinazoline-2-carboxylate (CAS 866155-30-8)
- N-(2-bromo-6-nitrophenyl)acetamide (CAS 245115-83-7)
- 3-[4-Bromo-2-(tert-butyl)phenoxy]azetidine (CAS 1146960-47-5)
- 6-Chloro-8-methyl-3-propylquinolin-2-amine (CAS 948293-52-5)
- 2-Hydroxy-5-(2-(2-mercapto-4-oxo-4,5-dihydrothiazol-5-yl)acetamido)benzoic acid (CAS 1142207-15-5)
- Methyl 2,2-dimethylchroman-8-carboxylate (CAS 1350761-44-2)
- 2-Cyclopentyl-5-methoxy-6,7-dimethyl-2,3-dihydro-1H-inden-1-one (CAS 41715-83-7)
- 2-Amino-5-ethylthiophene-3-carboxamide (CAS 343270-71-3)
- Tau Peptide (274-288) trifluoroacetate salt (CAS 330456-39-8)
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