4,4,5,5-Tetramethyl-2-(4-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane CAS 474709-28-9
| CAS No. | 474709-28-9 |
| Molecular Formula | C13H16BF3O3 |
| Molecular Weight | 288.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4,4,5,5-Tetramethyl-2-(4-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (CAS 474709-28-9) is a high-purity analytical reference standard with the molecular formula C13H16BF3O3 and a molecular weight of 288.07 g/mol.
The molecular framework of 4,4,5,5-Tetramethyl-2-(4-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (C13H16BF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H16BF3O3 |
| Molecular Weight | 288.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Tetramethyl Standards
- 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)phenol (CAS 1029439-76-6)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)phenol (CAS 1243143-45-4)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol (CAS 1256944-93-0)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridin-2-amine (CAS 1558927-41-5)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridin-2-amine (CAS 1628185-65-8)
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol (CAS 1638624-76-6)
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)phenol (CAS 2055742-98-6)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol (CAS 2638502-47-1)
Recommended Standards
- 4,4,5,5-Tetramethyl-2-(2-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (CAS 832114-04-2)
- 7-Iodo-2,3,4,5-tetrahydro-1-benzoxepin-5-one (CAS 1094350-52-3)
- 4-(Trifluoromethyl)-2-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)phenol (CAS 2096998-36-4)
- (S)-2-(5,6-Dichloro-1,3-dioxoisoindolin-2-yl)propanoic acid (CAS 111104-26-8)
- 9-(3-Bromophenyl)-10-(naphthalen-2-yl)anthracene (CAS 943861-20-9)
- N,3-dimethylazetidin-3-amine (CAS 149696-11-7)
- 3,4-Difluoro-2-methoxyaniline sulfate (CAS 1072945-56-2)
- 1-(Cyclopropylmethyl)-4-(2,6-dimethylphenyl)-3-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 860789-21-5)
- 5-Isopropyl-1H-pyrazole-3-carbohydrazide (CAS 1038997-09-9)
- Parecoxib Impurity 48 (CAS 198470-92-7)
- N-(3-(1H-Imidazol-1-yl)propyl)-N-(7-chloro-4-methoxybenzo[d]thiazol-2-yl)-2-phenylacetamide hydrochloride (CAS 1217053-90-1)
- Bevantolol (CAS 59170-23-9)
- Methyl 4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][2,7]naphthyridine-5-carboxylate (CAS 866050-65-9)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com