Sucralose Impurity 2 CAS 475491-24-8
| CAS No. | 475491-24-8 |
| Molecular Formula | C12H19F3O8 |
| Molecular Weight | 348.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sucralose Impurity 2 (CAS 475491-24-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H19F3O8 and a molecular weight of 348.27 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Sucralose Impurity 2 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 348.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sucralose Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H19F3O8 |
| Molecular Weight | 348.27 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Sucralose Standards
- Sucralose Impurity 4 (CAS CATO-C4X-28294)
- Sucralose EP Impurity F (CAS 61854-83-9)
- Sucralose EP Impurity G (CAS 105066-20-4)
- Sucralose EP Impurity E (CAS 55832-24-1)
- Sucralose EP Impurity B (CAS 40631-75-2)
- Sucralose (CAS 56038-13-2)
- Sucralose-d6 (CAS 1459161-55-7)
- Sucralose EP Impurity A (CAS 105066-21-5)
Recommended Standards
- N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)thiomorpholine-4-carboxamide (CAS 874298-05-2)
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- 2-(1H-Indol-3-yl)-2-oxo-N-[3-(trifluoromethoxy)phenyl]acetamide (CAS 1023559-26-3)
- Ethyl 2-amino-8-(perfluoroethyl)-3H-benzo[b]azepine-4-carboxylate (CAS 926927-42-6)
- Tolvaptan impurity 115 (CAS CATO-C4X-1955115)
- Papaverine Impurity 36 (CAS 82463-46-5)
- Relugolix Impurity 26 (CAS CATO-C4X-242926)
- 2-Boc-6-chloro-3,4-dihydro-1H-isoquinoline-1-carboxylic acid (CAS 871730-33-5)
- Bis(4-nonylphenyl) perylene-3,10-dicarboxylate (CAS 104989-10-8)
- 8-Bromo-5-methoxypyrido[3,4-b]pyrazine (CAS 1590409-72-5)
- (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid (CAS 169209-63-6)
- 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (CAS 99087-42-0)
- benzyl (4S)-1-methyl-2,6-dioxo-hexahydropyrimidine-4-carboxylate (CAS 103300-85-2)
- HA Peptide (CAS 92000-76-5)
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