4-(trifluoromethyl)dihydro-2H-pyran-2,6(3H)-dione CAS 4759-65-3
| CAS No. | 4759-65-3 |
| Molecular Formula | C6H5F3O3 |
| Molecular Weight | 182.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(trifluoromethyl)dihydro-2H-pyran-2,6(3H)-dione (CAS 4759-65-3) is a high-purity analytical reference standard with the molecular formula C6H5F3O3 and a molecular weight of 182.10 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 4-(trifluoromethyl)dihydro-2H-pyran-2,6(3H)-dione is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 182.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5F3O3 |
| Molecular Weight | 182.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related trifluoromethyl Standards
- 3-Oxo-1-(trifluoromethyl)cyclobutanecarboxylic acid (CAS 1803610-99-2)
- 5-(Trifluoromethyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid (CAS 1823489-59-3)
- 2-(5-(Trifluoromethyl)-1,3,4-oxadiazol-2-yl)ethan-1-ol (CAS 1934973-39-3)
- 7-(trifluoromethyl)-1,4-diazepan-5-one (CAS 1146290-50-7)
- Methyl 1-(trifluoromethyl)cyclobutane-1-carboxylate (CAS 1188909-22-9)
- ethyl 2-(trifluoromethyl)but-2-enoate (CAS 1215018-51-1)
- 6-(trifluoromethyl)pyridazine-3-carbaldehyde (CAS 1245643-49-5)
- 5-(Trifluoromethyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1253888-79-7)
Recommended Standards
- 3-(2,2,2-Trifluoroacetyl)dihydrofuran-2(3H)-one (CAS 69243-04-5)
- Ethyl 2-diazo-3,3,3-trifluoro-propionate (CAS 59733-95-8)
- N-(2-azidoethyl)-2,2,2-trifluoroacetamide (CAS 72200-25-0)
- Trifluridine Impurity 10 (CAS 2145-56-4)
- (5-(3-Iodopropoxy)-2-nitrophenyl)methanol (CAS 185994-27-8)
- 8-Bromo-2,3-dimethyl-1,4-dihydroquinolin-4-one (CAS 3953-95-5)
- 5-aminopyridine-2-carboxylic acid, HCl (CAS 78273-25-3)
- 2,5-Dimethyl-1-(2-methylpropyl)-1H-pyrrole-3-carbaldehyde (CAS 730950-24-0)
- N-(4-Biphenylyl)-2-naphthylamine (CAS 6336-92-1)
- 2-(5-methyl-1,3-thiazol-2-yl)propan-1-amine (CAS 1017392-90-3)
- 5-(Chloromethyl)-4-phenyl-4H-1,2,4-triazole-3-carboxamide (CAS 114370-69-3)
- Methyl 10-hydroxyoctadecanoate (CAS 2380-01-0)
- 2-Bromo-1-ethynyl-4-methoxybenzene (CAS 871126-87-3)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com